Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols

Fangxia Shen; Miaomiao Tan; Zhenxing Wang; Maosheng Yao; Zhenqiang Xu; Yan Wu; Jindong Wang; Xuefeng Guo; Tong Zhu

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Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols

机译：集成硅纳米线场效应晶体管，微流控技术和空气采样技术，用于实时监测生物气溶胶

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Numerous threats from biological aerosol exposures, such as those from H1N1 influenza, SARS, bird flu, and bioterrorism activities necessitate the development of a real-time bioaerosol sensing system, which however is a long-standing challenge in the field. Here, we developed a real-time monitoring system for airborne influenza H3N2 viruses by integrating electronically addressable silicon nanowire (SiNW) sensor devices, microfluidics and bioaero-sol-to-hydrosol air sampling techniques. When airborne influenza H3N2 virus samples were collected and delivered to antibody-modified SiNW devices, discrete nanowire conductance changes were observed within seconds. In contrast, the conductance levels remained relatively unchanged when indoor air or clean air samples were delivered. A 10-fold increase in virus concentration was found to give rise to about 20—30% increase in the sensor response. The selectivity of the sensing device was successfully demonstrated using H1N1 viruses and house dust allergens. From the simulated aerosol release to the detection, we observed a time scale of 1—2 min. Quantitative pob/merase chain reaction (qPCR) tests revealed that higher virus concentrations in the air samples generally corresponded to higher conductance levels in the SiNW devices. In addition, the display of detection data on remote platforms such as cell phone and computer was also successfully demonstrated with a wireless module. The work here is expected to lead to innovative methods for biological aerosol monitoring, and further improvements in each of the integrated elements could extend the system to real world applications.

机译：来自生物气溶胶暴露的许多威胁，例如来自H1N1流感，SARS，禽流感和生物恐怖主义活动的威胁，都需要开发实时生物气溶胶传感系统，但这是该领域的长期挑战。在这里，我们通过集成可电子寻址的硅纳米线（SiNW）传感器设备，微流控技术和生物气溶胶-水溶胶空气采样技术，开发了一种机载H3N2流感病毒实时监控系统。当收集空气传播的H3N2流感病毒样本并将其递送至抗体修饰的SiNW设备时，几秒钟内即可观察到离散的纳米线电导率变化。相反，当递送室内空气或清洁空气样品时，电导水平保持相对不变。发现病毒浓度增加10倍会使传感器响应提高20-30％。使用H1N1病毒和屋尘过敏原已成功证明了传感装置的选择性。从模拟的气溶胶释放到检测，我们观察到的时间范围为1-2分钟。定量pob / merase链反应（qPCR）测试表明，空气样本中较高的病毒浓度通常对应于SiNW设备中较高的电导率水平。此外，无线模块还成功演示了检测数据在手机和计算机等远程平台上的显示。预期这里的工作将导致创新的生物气溶胶监测方法，并且对每个集成元素的进一步改进可能会将系统扩展到实际应用中。

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来源
《Environmental Science & Technology》 |2011年第17期|p.7473-7480|共8页
作者
Fangxia Shen; Miaomiao Tan; Zhenxing Wang; Maosheng Yao; Zhenqiang Xu; Yan Wu; Jindong Wang; Xuefeng Guo; Tong Zhu;
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作者单位

State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering.Peking University, Beijing 100871, China;

State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering.Peking University, Beijing 100871, China;

Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species,College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;

State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering.Peking University, Beijing 100871, China;

State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering.Peking University, Beijing 100871, China;

State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering.Peking University, Beijing 100871, China;

Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species,College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;

Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species,College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;

State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering.Peking University, Beijing 100871, China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols

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