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首页> 外文期刊>Environmental Science & Technology >Effects of Gene-Environmental Interaction on Noise-Induced Hearing Threshold Levels for High Frequencies (HTLHF)
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Effects of Gene-Environmental Interaction on Noise-Induced Hearing Threshold Levels for High Frequencies (HTLHF)

机译：基因-环境相互作用对高频噪声诱导的听力阈值水平的影响

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摘要

In this study we assessed the interaction between glutathione S-transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies (HTLHF). Research participants comprised 347 male workers, and each participant's cumulative noise exposure was determined using a job—exposure matrix. Approximately 64.696 of the participants' exposure in Leq-8_h was above 90 dBA The mean HTLHF was 32.1 dB. A significant dose—response relationship was found between noise exposure and HTLHF. We further converted the estimated total noise exposure level over each participant's job history to a noise exposure level that corresponded to a 40-year exposure (L_(eq-40y)). After we had adjusted the results for age, we found that workers carrying GSTM1 null, GSTT1 null, and GSTP1 Ile~(10s)/Ile105 genotypes were susceptible to the HTLHF when their L_(eq-40y) were above 90 dBA. Therefore, GST genetic polymorphisms might affect HTLHF only when workers are exposed to high noise levels.
机译：在这项研究中，我们评估了谷胱甘肽S-转移酶（GST）遗传多态性与噪声暴露之间的相互作用，以及它们对高频听力阈值水平（HTLHF）的影响。研究参与者包括347名男性工人，每个参与者的累积噪声暴露是使用工作-暴露矩阵确定的。 Leq-8_h中约64.696的参与者暴露高于90 dBA。平均HTLHF为32.1 dB。发现噪声暴露与HTLMF之间存在显着的剂量反应关系。我们进一步将每个参与者的工作经历的估计总噪声暴露水平转换为对应于40年暴露水平的噪声暴露水平（L_（eq-40y））。在根据年龄调整结果之后，我们发现携带GSTM1 null，GSTT1 null和GSTP1 Ile〜（10s）/ Ile105基因型的工人在L_（eq-40y）高于90 dBA时易受HTLHF的影响。因此，商品及服务税的遗传多态性可能仅在工人暴露于高噪声水平时才影响HTLHF。

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  • 来源
    《Environmental Science & Technology》 |2011年第17期|p.7128-7134|共7页
  • 作者

    Cheng-Yu Lin; Tung-Sheng Shih; Yue-Liang Leon Guo; Jiunn-Liang Wu; Yih-Min Sun; Perng-Jy Tsai;

  • 作者单位

    Department of Otolaryngology, Tainan Hospital, Department of Health, 125 Zhongshan Road, West Central District, Tainan City 700,Taiwan Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, 138 Sheng-Li Road, North District, Tainan City 704, Taiwan Department of Otolaryngology, Medical College and Hospital, National Cheng Kung University, 138 Sheng-Li Road, North District, Tainan City 704, Taiwan;

    Institute of Occupational Safety and Health, Council of Labor Affairs, Executive Yuan, 99, Lane 407, Heng-Ke Road, Si-Jhih City, Taipei County 221, Taiwan Department of Occupational Safety and Health, College of Public Health, China Medical University, 91 Hsueh-Shih Road,Taichung City 404, Taiwan;

    Department of Environmental and Occupational Medicine, Medical College, National Taiwan University, Room C339,17 Syu-Jhou Road, Jhong-Jheng District, Taipei City 100, Taiwan;

    Department of Otolaryngology, Medical College and Hospital, National Cheng Kung University, 138 Sheng-Li Road, North District, Tainan City 704, Taiwan;

    Department of Occupational Safety and Health, Chung Hwa University of Medical Technology, 89 Wun-Hua First Street,Ren-De Township, Tainan County 717, Taiwan;

    Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, 138 Sheng-Li Road, North District, Tainan City 704, Taiwan Department of Occupational Safety and Health, College of Public Health, China Medical University, 91 Hsueh-Shih Road,Taichung City 404, Taiwan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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