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Temporal Changes in the Levels of Perfluorinated Compounds in California Women's Serum over the Past 50 Years

机译:过去50年中加利福尼亚女性血清中全氟化合物水平的时间变化

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摘要

Serum samples collected from California women at different time periods: 1960s (n= 40), 1980s (n = 30), and 2009 (n = 35) were examined for the presence of 12 perfluorinated compounds (PFCs) using an online SPE-HPLC-MS/MS method. At each time period, perfluorooctane sulfonate (PFOS) was present at the highest concentration, followed by perfluorooctanoic acid (PFOA, except in the 1960s). We found the highest levels of PFOS (median = 42.1 ng/ mL) and perflfluorohexane sulfonate (PFHxS, median = 1.56 ng/mL) in the 1960s samples, possibly reflecting widespread use of precursor PFCs. PFOS showed a statistically significant drop from the 1960s to the 1980s (28.8 ng/mL ) and to 2009 (9.0 ng/mL ), the latter being in agreement with national data. For PFOA, there was an approximately 10-fold increase in median concentrations from the 1960s (0.27 ng/ mL) to thel980s (2.71 ng/mL), and a slight drop in the 2009 samples (2.08 ng/mL). For longer chain perfluorocarboxyuc acids (PFCAs), there was a continuous buiid-up in serum from the 1960s to 2009. To our knowledge, this is the first study to investigate temporal changes of PFCs over the past 50 years.
机译:使用在线SPE-HPLC检查了1960年代(n = 40),1980年代(n = 30)和2009(n = 35)在不同时间段从加利福尼亚女性那里收集的血清样品中是否存在12种全氟化合物(PFC) -MS / MS方法。在每个时间段,全氟辛烷磺酸盐(PFOS)的浓度最高,其次是全氟辛酸(PFOA,1960年代除外)。我们在1960年代的样品中发现了最高水平的全氟辛烷磺酸(中位数= 42.1 ng / mL)和全氟己烷磺酸盐(PFHxS,中位数= 1.56 ng / mL),这可能反映了前体PFC的广泛使用。从1960年代到1980年代(28.8 ng / mL)和2009年(9.0 ng / mL),全氟辛烷磺酸在统计上显着下降,后者与国家数据一致。对于PFOA,从1960年代(0.27 ng / mL)到2000年代(2.71 ng / mL)的中位浓度大约增加10倍,2009年样品(2.08 ng / mL)略有下降。对于更长链的全氟羧酸(PFCA),从1960年代到2009年,血清中一直持续增加血红蛋白。据我们所知,这是研究过去50年来PFC的时间变化的第一项研究。

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  • 来源
    《Environmental Science & Technology》 |2011年第17期|p.7510-7516|共7页
  • 作者单位

    Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, California 94710, United State;

    Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, California 94710, United State;

    Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, California 94710, United State;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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