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首页> 外文期刊>Environmental Science & Technology >Polychlorinated Naphthalenes (PCNs): Congener Specific Analysis, Occurrence in Food, and Dietary Exposure in the UK
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Polychlorinated Naphthalenes (PCNs): Congener Specific Analysis, Occurrence in Food, and Dietary Exposure in the UK

机译：多氯萘（PCN）：同系物特定分析，食品中的发生率和英国的饮食暴露

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摘要

Information on the occurrence of toxicologically significant polychlorinated naphthalenes (PCNs) in food, or on human exposure, is sparse. In this work, PCN congeners (PCNs 52, 53,66/67,68,69,71/72,73,74, and 75) were selected for analysis, based on the available literature on current occurrence and toxicology, and limited by the commercial availability of reference standards. The analytical methodology used cold solvent extraction of prehydrolyzed samples fortified with internal standards (~(13)C_(10) labeled PCNs), activated carbon and basic alumina purification, and measurement by HRGC-HRMS. The investigation showed PCN occurrence in all studied foods: meat milk, fish, dairy and meat products, eggs, poultry, vegetables, fruits, etc. The most frequently detected congeners were PCN 52, PCNs 66/67, and PCN 73. The highest concentrations were observed in fish (maximum value of 37 ng/kg w.w. for the sum of the measured congeners). The dioxin-like toxicrty (PCN TEQ) associated with these concentrations is 1 -2 orders of magnitude lower than those reported for chlorinated dioxins or PCBs in food and, on the basis of dietary intakes estimated using very conservative assumptions regarding concentrations of these contaminants in the UK, the levels of PCNs alone in food do not suggest any toxicological concerns.
机译：关于食物中有毒理学意义的多氯萘（PCNs）的发生或人体暴露的信息很少。在这项工作中，根据有关当前发生情况和毒理学的现有文献，选择了PCN同系物（PCN 52、53、66 / 67、68、69、71 / 72、73、74和75）进行分析，并受限于参考标准的商业可用性。该分析方法学使用冷溶剂萃取预水解样品，该样品经内标强化（〜（13）C_（10）标记为PCNs），活性炭和碱性氧化铝纯化，并通过HRGC-HRMS测量。调查显示，在所有研究的食物中均存在PCN：肉奶，鱼，乳制品和肉制品，鸡蛋，家禽，蔬菜，水果等。最常见的同源物是PCN 52，PCN 66/67和PC​​N 73。在鱼中观察到浓度（测量的同类物总和的最大值为37 ng / kg ww）。与这些浓度相关的类二恶英类毒性（PCN TEQ）比食品中氯化二恶英或PCBs所报告的二恶英类毒性低1-2个数量级，并且是根据非常保守的假设对饮食中的这些污染物的浓度进行估算得出的膳食摄入量在英国，仅食品中PCN的含量并不表示任何毒理学问题。

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  • 来源
    《Environmental Science & Technology》 |2010年第9期|P.3533-3538|共6页
  • 作者

    ALWYN FERNANDES; rnDAVID MORTIMER; rnMARTIN GEM; rnFRANKIE SMITH; rnMARTIN ROSE; rnSEAN PANTON; rnMELANIE CARR;

  • 作者单位

    Food and Environment Research Agency, Sand Hutton, York YO41 1LZ U.K.;

    rnFood Standards Agency, Aviation House, 125 Kingsway, London, WC2B 6NH U.K.;

    rnFood Standards Agency, Aviation House, 125 Kingsway, London, WC2B 6NH U.K.;

    rnFood and Environment Research Agency, Sand Hutton, York YO41 1LZ U.K.;

    rnFood and Environment Research Agency, Sand Hutton, York YO41 1LZ U.K.;

    rnFood and Environment Research Agency, Sand Hutton, York YO41 1LZ U.K.;

    rnFood and Environment Research Agency, Sand Hutton, York YO41 1LZ U.K.;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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