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首页> 外文期刊>Environmental Science & Technology >Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity
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Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity

机译：使用快速，体外测试的内分泌和其他生物活性分析八种漏油分散剂

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摘要

The Deepwater Horizon oil spill has led to the use of >1 M gallons of oil spill dispersants, which are mixtures of surfactants and solvents. Because of this large scale use there is a critical need to understand the potential for toxicity of the currently used dispersant and potential alternatives, especially given the limited toxicity testing information that is available. In particular, some dispersants contain nonylphenol ethoxylates INPEs), which can degrade to nonylphenol (NP), a known endocrine disrupter. Given the urgent need to generate toxicity data, we carried out a series of in vitro high-throughput assays on eight commercial dispersants. These assays focused on the estrogen and androgen receptors (ER and AR), but also included a larger battery of assays probing other biological pathways. Cytotoxicity in mammalian cells was also quantified. No activity was seen in any AR assay. Two dispersants showed a weak ER signal in one assay IEC50 of 16 ppm for Nokomis 3-F4 and 25 ppm for ZI-400). NPs and NPEs also had a weak signal in this same ER assay. Note that Corexit 9500, the currently used product, does not contain NPEs and did not show any ER activity. Cytotoxicity values for six of the dispersants were statistically indistinguishable, with median LC50 values ～100 ppm. Two dispersants, JD 2000 and SAF-RON GOLD, were significantly less cytotoxic than the others with LC50 values approaching or exceeding 1000 ppm.
机译：Deepwater Horizo​​n溢油已导致使用> 1 M加仑的溢油分散剂，这些分散剂是表面活性剂和溶剂的混合物。由于这种大规模的使用，因此迫切需要了解当前使用的分散剂的毒性潜力和潜在的替代品，尤其是在可获得的毒性测试信息有限的情况下。特别地，一些分散剂包含壬基酚乙氧基化物（INPEs），其可以降解为已知的内分泌干扰物壬基酚（NP）。鉴于迫切需要生成毒性数据，我们对八种市售分散剂进行了一系列体外高通量分析。这些测定法侧重于雌激素和雄激素受体（ER和AR），但也包括更多探测其他生物学途径的测定法。还定量了哺乳动物细胞中的细胞毒性。在任何AR测定中均未观察到活性。两种分散剂在一项试验IEC50中显示弱的ER信号，对于Nokomis 3-F4为16 ppm，对于ZI-400为25 ppm。在相同的ER分析中，NP和NPE的信号也较弱。请注意，当前使用的产品Corexit 9500不包含NPE，也没有显示任何ER活性。六种分散剂的细胞毒性值在统计学上无法区分，LC50的中值约为100 ppm。 LC50值接近或超过1000 ppm时，两种分散剂JD 2000和SAF-RON GOLD的细胞毒性显着低于其他分散剂。

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  • 来源
    《Environmental Science & Technology》 |2010年第15期|p.5979-5985|共7页
  • 作者

    RICHARD S. JUDSON; rnMATTHEW T. MARTIN; rnDAVID M. REIF; rnKEITH A. HOUCK; rnTHOMAS B. KNUDSEN; rnDANIEL M. ROTROFF; rnMENGHANG XIA; rnSRILATHA SAKAMURU; rnRUILI HUANG; rnPAUL SHINN; rnCHRISTOPHER P. AUSTIN; rnROBERT I. KAVLOCK; rnDAVID I. DIX;

  • 作者单位

    National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711;

    rnNational Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711;

    rnNational Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711;

    rnNational Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711;

    rnNational Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711;

    rnNational Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711;

    rnNIH Chemical Genomics Center, National Institutes of Health Department of Health and Human Services,Bethesda,Maryland 20892;

    rnNIH Chemical Genomics Center, National Institutes of Health Department of Health and Human Services,Bethesda,Maryland 20892;

    rnNIH Chemical Genomics Center, National Institutes of Health Department of Health and Human Services,Bethesda,Maryland 20892;

    rnNIH Chemical Genomics Center, National Institutes of Health Department of Health and Human Services,Bethesda,Maryland 20892;

    rnNIH Chemical Genomics Center, National Institutes of Health Department of Health and Human Services,Bethesda,Maryland 20892;

    rnNational Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711;

    rnNational Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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