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首页> 外文期刊>Environmental Science & Technology >Reproductive Consequences Of Paternal Genotoxin Exposure In Marine Invertebrates
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Reproductive Consequences Of Paternal Genotoxin Exposure In Marine Invertebrates

机译：海洋无脊椎动物父系基因毒素暴露的生殖后果

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摘要

Chemicals with the potential to damage DNA are increasingly present in the marine environment; yet our understanding of the long-term consequences of DNA damage for populations remains limited. We explore the impact of paternal genotoxin exposure on the reproductive biology of two ecologically important free-spawning marine invertebrates: the polychaete Arenicola marina and the mussel Mytilus edulis. Males were exposed in vivo for 72 h to methyl methanesulfonate and benzo(a)pyrene and the impact on somatic cells and sperm assessed using the Comet assay. A strong correlation between DNA damage in somatic cells and sperm was observed after 24 h exposure (P < 0.001). Recovery in sperm was significantly lower than in coelomocytes after 72 h. The fertilization success of DNA-damaged sperm was unaffected, but a significant percentage of embryos derived from sperm with induced DNA damage exhibited severe developmental abnormalities within 24 h of fertilization with potential long-term consequences for population success. Further research is required to determine the mechanism by which paternal DNA damage causes disruption of development at this early stage.
机译：在海洋环境中，越来越有可能破坏DNA的化学物质。但是，我们对DNA损伤对人群的长期后果的理解仍然有限。我们探索父本基因毒素暴露对两个生态上重要的自由产卵的海洋无脊椎动物无性繁殖的影响：多毛Are Arenicola marina和贻贝Mytilus edulis。雄性在体内暴露于甲磺酸甲酯和苯并（a）re 72小时，并使用Comet分析评估对体细胞和精子的影响。暴露24 h后，观察到体细胞DNA损伤与精子之间有很强的相关性（P <0.001）。 72小时后，精子的恢复显着低于内皮细胞。受DNA损伤的精子的受精成功不会受到影响，但是受精DNA诱导DNA损伤的精子中有很大比例的胚胎在受精后的24小时内表现出严重的发育异常，对种群成功具有潜在的长期影响。需要进一步的研究来确定父本DNA损伤在此早期阶段破坏发育的机制。

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  • 来源
    《Environmental Science & Technology》 |2009年第3期|928-933|共6页
  • 作者

    CERI LEWIS; TAMARA GALLOWAY;

  • 作者单位

    School of Biosciences, Hatherley Laboratories, University of Exeter, Prince of Wales Road, Exeter, United Kingdom, ES4 4PS;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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