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首页> 外文期刊>Environmental Science & Technology >Genotoxicity of Environmentally Relevant Concentrations of Water-Soluble Oil Components in Cod (Gadus morhua)
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Genotoxicity of Environmentally Relevant Concentrations of Water-Soluble Oil Components in Cod (Gadus morhua)

机译：鳕鱼中水溶性油成分的环境相关浓度的遗传毒性

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摘要

Large discharges from oil and gas production platforms (produced water) have led to concerns for adverse biological effects in marine areas. The aim of this study was to investigate the development of DNA adduct formation and related biomarkers in fish after chronic exposure to water-soluble components of oil. Atlantic cod (Gadus morhua) were exposed for up to 44 weeks to three treatments (low, pulsed, high) containing environmentally relevant concentrations of low-molecular-weight polycyclic aromatic hydrocarbons (PAHs) and short-chained alkylphenols (APs). A time- and dose-related pattern of DNA adduct formation (measured using ~(32)P-postlabeling) was observed. The results suggested that an extended exposure period (more than 16 weeks) would be required for the formation of DNA adduct levels above background. Interestingly, fish receiving pulsed high exposure did not develop elevated concentrations of DNA adducts, possibly due to DNA repair processes. No obvious relationship between DNA adduct concentration and cytochrome P4501A activity (EROD) was observed. This study has demonstrated the genotoxic potential of water-soluble oil components, relevant for operational discharges (produced water) and chronic oil spills. The quantification of PAH metabolites in bile and hepatic DNA adduct formation appear to be suitable for environmental monitoring of chronic oil pollution.
机译：石油和天然气生产平台（产出水）的大量排放已引起人们对海洋地区有害生物影响的关注。这项研究的目的是调查鱼类在长期暴露于油的水溶性成分后DNA加合物形成和相关生物标记物的发展。大西洋鳕（Gadus morhua）暴露于含有环境相关浓度的低分子量多环芳烃（PAHs）和短链烷基酚（APs）的三种处理（低，脉冲，高）长达44周。观察到了DNA加合物形成的时间和剂量相关模式（使用〜（32）P后标记测量）。结果表明，要形成高于本底的DNA加合物水平，需要延长暴露时间（超过16周）。有趣的是，受到脉冲高暴露的鱼类可能不会由于DNA修复过程而导致DNA加合物浓度升高。没有观察到DNA加合物浓度与细胞色素P4501A活性（EROD）之间的明显关系。这项研究证明了水溶性油成分的潜在遗传毒性，与操作性排放（产出水）和长期漏油有关。胆汁和肝DNA加合物形成中PAH代谢产物的定量似乎适用于慢性油污染的环境监测。

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  • 来源
    《Environmental Science & Technology》 |2009年第9期|3329-3334|共6页
  • 作者

    TOR F. HOLTH; BJORNAR A. BEYLICH; HALLDORA SKARPHEDINSDOTTIR; BIRGITTA LIEWENBORG; MERETE GRUNG; KETIL HYLLAND;

  • 作者单位

    Norwegian Institute for Water Research (NIVA), CIENS, Gaustadalleen 21, NO-0349 Oslo, Norway Department of Biology, University of Oslo, PO Box 1066 Blindern, N-0316 Oslo, Norway;

    Norwegian Institute for Water Research (NIVA), CIENS, Gaustadalleen 21, NO-0349 Oslo, Norway;

    Department of Applied Environmental Science (ITM), Environmental Toxicology and Chemistry (ITMx), Stockholm University, SE-106 91 Stockholm, Sweden;

    Department of Applied Environmental Science (ITM), Environmental Toxicology and Chemistry (ITMx), Stockholm University, SE-106 91 Stockholm, Sweden;

    Norwegian Institute for Water Research (NIVA), CIENS, Gaustadalleen 21, NO-0349 Oslo, Norway;

    Norwegian Institute for Water Research (NIVA), CIENS, Gaustadalleen 21, NO-0349 Oslo, Norway Department of Biology, University of Oslo, PO Box 1066 Blindern, N-0316 Oslo, Norway;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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