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首页> 外文期刊>Environmental Science & Technology >Accumulation, Subcellular Distribution and Toxicity of Copper in Earthworm (Eisenia fetida) in the Presence of Ciprofloxacin
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Accumulation, Subcellular Distribution and Toxicity of Copper in Earthworm (Eisenia fetida) in the Presence of Ciprofloxacin

机译：环丙沙星存在下Earth（Eisenia fetida）中铜的积累，亚细胞分布和毒性

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摘要

Land application of wastes from concentrated animal feeding operations results in accumulation of copper (Cu) and antimicrobials in terrestrial systems. Interaction between Cu and antimicrobials may change Cu speciation in soil solution, and affect Cu bioavailability and toxicity. In this study, earthworms were exposed to quartz sand percolated with different concentrations of Cu and ciprofloxacin (CIP). Copper uptake by earthworms, its subcellular partition, and toxicity were studied. An increase in the applied CIP decreased the free Cu ion concentration in external solution and mortalities of earthworm, while Cu contents in earthworms increased. Copper and CIP in earthworms were fractionated into five fractions: a granular fraction (D), a fraction consisting of tissue fragments, cell membranes, and intact cells (E), a microsomal fraction (F), a denatured proteins fraction (G),and a heat-stable proteins fraction (H). Most of the CIP in earthworms was in fraction H. Copper was redistributed from the metal-sensitive fraction E to fractions D, F, G, and H with increasing CIP concentration. These results challenge the free ion activity model and suggested that Cu may be partly taken up as Cu-CIP complexes in earthworms, changing the bioavailability, subcellular distribution, and toxicity of Cu to earthworms.
机译：集中动物饲养操作产生的土地废弃物导致陆地系统中铜（Cu）和抗菌剂的积累。铜与抗菌剂之间的相互作用可能会改变土壤溶液中的铜形态，并影响铜的生物利用度和毒性。在这项研究中，earth暴露于渗透有不同浓度的铜和环丙沙星（CIP）的石英砂中。研究了worm对铜的吸收，其亚细胞分配和毒性。施用的CIP的增加降低了external的外部溶液中的铜离子浓度和死亡率，而earth中的铜含量增加。将earth中的铜和CIP分为五个级分：颗粒级分（D），由组织碎片，细胞膜和完整细胞组成的级分（E），微粒体级分（F），变性蛋白质级分（G），和热稳定的蛋白质部分（H）。 in中的大多数CIP都在H组分中。随着CIP浓度的增加，铜从金属敏感性组分E中重新分布到D，F，G和H组分中。这些结果挑战了自由离子活性模型，并暗示了铜可能部分地作为as中的Cu-CIP复合物吸收，从而改变了Cu对to的生物利用度，亚细胞分布和毒性。

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  • 来源
    《Environmental Science & Technology》 |2009年第10期|3688-3693|共6页
  • 作者

    RIXIANG HUANG; BEI WEN; ZHIGUO PEI; XIAO-QUAN SHAN; SHUZHEN ZHANG; PAUL N. WILLIAMS;

  • 作者单位

    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;

    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;

    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;

    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;

    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;

    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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