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首页> 外文期刊>Environmental Science & Technology >Biovolatilization of Metal(loid)s by Intestinal Microorganisms in the Simulator of the Human Intestinal Microbial Ecosystem
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Biovolatilization of Metal(loid)s by Intestinal Microorganisms in the Simulator of the Human Intestinal Microbial Ecosystem

机译：在人类肠道微生物生态系统中，肠道微生物对金属（金属）的生物挥发作用

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摘要

Methylation and hydrogenation of metal(loid)s by microorganisms are widespread and well-known processes in the environment by which mobility and in most cases toxicrty are significantly enhanced in comparison to inorganic species. The human gut contains highly diverse and active microbiocenosis, yet little is known about the occurrence and importance of microbial metal(loid) methylation and hydrogenation. In this study, an in vitro gastrointestinal model, the Simulator of the Human Intestinal Microbial Ecosystem(SHIME),was used for investigating volatilization of metal(loid)s by intestinal microbiota. Suspensions from different compartments of the SHIME system analogous to different parts of the human intestinal tract were incubated with different concentrations of inorganic Ge, As, Se, Sn, Sb, Te, Hg, Pb, and Bi and analyzed by gas chromatography and inductively coupled plasma mass spectrometry (GC-ICP-MS). Significant volatilization was found for Se, As, and Te (maximal hourly production rates relative to the amount spiked; 0.6, 2, and 9 ng/mg/h, respectively). In addition, volatile species of Sb and Bi were detected. The occurrence of AsH_3 and (CH_3)Te wastoxicologically important Furthermore, mixed Se/S and mixed As/S metabolites were detected in significant amounts in the gas phase of the incubation experiments of which two metabolites, (CH_3)_2AsSSCH_3 and CH_3As(SCH_3)_2, are described for the first time in environmental matrices. The toxicology of these species is unknown. These data show that the intestinal microbiota may increase the mobility of metal(loid)s, suggesting a significant modulation of their toxicity. Our research warrants further studies to investigate the extent of this process as well as the availability of metal(loid)s from different sources for microbial transformations.
机译：在环境中，微生物对金属（甲基）进行甲基化和氢化是广泛而众所周知的过程，与无机物质相比，通过该过程可大大提高其迁移率和大多数情况下的毒性。人的肠道含有高度多样化和活跃的微生物群落，但对微生物金属（甲基）甲基化和氢化的发生及其重要性了解甚少。在这项研究中，体外胃肠道模型，人类肠道微生物生态系统（SHIME）的模拟器，用于研究肠道菌群对金属（胶体）的挥发。将来自SHIME系统不同隔室的悬浮液（类似于人体肠道的不同部分）与不同浓度的无机Ge，As，Se，Sn，Sb，Te，Hg，Pb和Bi孵育，然后通过气相色谱法和电感耦合法进行分析等离子质谱（GC-ICP-MS）。发现Se，As和Te的挥发很大（相对于加标量的最大每小时生产率；分别为0.6、2和9 ng / mg / h）。此外，还检测到了Sb和Bi的挥发性物质。 AsH_3和（CH_3）Te的出现具有毒理学重要性。此外，在孵育实验的气相中大量检测到混合的Se / S和As / S混合代谢物，其中有两种代谢物（CH_3）_2AsSSCH_3和CH_3As（SCH_3） _2是在环境矩阵中首次描述的。这些物质的毒理学未知。这些数据表明，肠道菌群可能会增加金属（金属）的迁移率，表明其毒性的显着调节。我们的研究值得进一步研究，以调查这一过程的程度以及微生物转化来源不同的金属（金属）的可用性。

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  • 来源
    《Environmental Science & Technology》 |2009年第14期|5249-5256|共8页
  • 作者

    ROLAND A. DIAZ-BONE; TOM R. VAN DE WIELE;

  • 作者单位

    Institute of Environmental Analytical Chemistry, University of Duisburg-Essen. Universitaetstrasse 3-5, 45141 Essen, Germany;

    Laboratory of Microbial Ecology and Technology, University of Gent, Belgium;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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