...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >MuKidrug Efflux Transporters Limit Accumulation of Inorganic, but Not Organic, Mercury in Sea Urchin Embryos
【24h】

MuKidrug Efflux Transporters Limit Accumulation of Inorganic, but Not Organic, Mercury in Sea Urchin Embryos

机译：MuKidrug外排转运蛋白可限制海胆胚胎中无机汞的积累，但不能限制有机汞的积累

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mercuric compounds are persistent global pollutants that accumulate in marine organisms and in humans who consume them. While the chemical cycles and speciation of mercury in the oceans are relatively well described, the cellular mechanisms that govern which forms of mercury accumulate in cells and why they persist are less understood. In this study we examined the role of multidrug efflux transport in the differential accumulation of inorganic (HgCl_2) and organic (CH_3HgCl) mercury in sea urchin (Strongylocentrotus purpuratus) embryos. We found that inhibition of MRP/ABCC-type transporters increases intracellular accumulation of inorganic mercury but had no effect on accumulation of organic mercury. Similarly, pharmacological inhibition of metal conjugating enzymes by ligands GST/GSH significantly increases this antimitotic potency of inorganic mercury, but had no effect on the potency of organic mercury. Our results point to MRP-mediated elimination of inorganic mercury conjugates as a cellular basis for differences in the accumulation and potency of the two major forms of mercury found in marine environments.
机译：汞化合物是持久性的全球污染物，会累积在海洋生物和食用它们的人类中。尽管对海洋中汞的化学循环和物种形态进行了较为详尽的描述，但对于控制哪种形式的汞在细胞中积累以及它们为何持续存在的细胞机制却鲜为人知。在这项研究中，我们研究了多药外排转运在海胆（Strongylocentrotus purpuratus）胚胎中无机（HgCl_2）和有机（CH_3HgCl）汞的差异积累中的作用。我们发现抑制MRP / ABCC型转运蛋白会增加细胞内无机汞的积累，但对有机汞的积累没有影响。同样，配体GST / GSH对金属结合酶的药理抑制作用显着提高了无机汞的抗有丝分裂能力，但对有机汞的效力没有影响。我们的研究结果指出，MRP介导的消除无机汞共轭物是海洋环境中两种主要形式的汞的累积和效价差异的细胞基础。

著录项

  • 来源
    《Environmental Science & Technology》 |2009年第21期|8374-8380|共7页
  • 作者

    IVANA BOSNJAK; KEVIN R. UHLINGER; WESLEY HEIM; TVRTKO SMITAL; JASNA FRANEKIC-COLIC; KENNETH COALE; DAVID EPEL; AMRO HAMDOUN;

  • 作者单位

    Laboratory for Biology and Microbial Genetics, Department for Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia;

    Hopkins Marine Station of Stanford University, 120 Oceanview Boulevard, Pacific Grove, California 93950;

    Marine Pollution Studies Laboratories, Moss Landing Marine Laboratories, 7544 Sandholdt Road, Moss Landing, California 95039;

    Laboratory for Molecular Ecotoxicology, Division for Marine and Environmental Research, Rufler Boskovic Institute, Bijenicka cesta 54, 10000 Zagreb, Croatia;

    Laboratory for Biology and Microbial Genetics, Department for Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia;

    Marine Pollution Studies Laboratories, Moss Landing Marine Laboratories, 7544 Sandholdt Road, Moss Landing, California 95039;

    Hopkins Marine Station of Stanford University, 120 Oceanview Boulevard, Pacific Grove, California 93950;

    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California, 92037;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号