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首页> 外文期刊>Environmental Science & Technology >Mutagenic and Carcinogenic Hazards of Settled House Dust II: Salmonella Mutagenicity
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Mutagenic and Carcinogenic Hazards of Settled House Dust II: Salmonella Mutagenicity

机译：定居房粉尘II的致突变和致癌危险：沙门氏菌致突变性

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Settled house dust (SHD) is a complex mixture that contains numerous chemical contaminants. Very little is known about the hazards of SHD as compared to other complex matrices such as air and soil. In this study, the mutagenic hazards associated with the extracts of sieved dust from 52 homes were examined using the Salmonella Mutagenicity Test. All of the SHD samples displayed mutagenic activity and the mean mutagenic potencies ranged from 2300 to 23 600 revertants per gram. Testing with various Salmonella strains revealed a predominance of frameshift mutagens in the dust samples. Analyses showed that polycyclic aromatic hydrocarbons (PAHs) were likely responsible for a quarter of the mutagenic activity of the SHD samples. In an effort to identify factors that influenced dust mutagenicity, the relationships between SHD mutagenicity and household activities were investigated. Mutagenicity was positively correlated with parameters such as the time since last vacuuming (r~2 = 0.11, p < 0.05) and the number of people living in the home (r~2 = 0.11-0.43, p < 0.05). However, the causative factors responsible for these relationships remain unclear.
机译：房屋灰尘（SHD）是一种复杂混合物，其中包含许多化学污染物。与其他复杂基质（如空气和土壤）相比，人们对SHD的危害知之甚少。在这项研究中，使用沙门氏菌致突变性测试检查了与来自52个家庭的筛分粉尘提取物相关的诱变危害。所有SHD样品均显示出诱变活性，平均诱变力范围为每克2300至23600个回复株。用各种沙门氏菌菌株进行的测试表明，灰尘样品中移码的诱变剂占主导地位。分析表明，多环芳烃（PAH）可能是SHD样品诱变活性的四分之一。为了确定影响粉尘致突变性的因素，研究了SHD致突变性与家庭活动之间的关系。致突变性与自上次吸尘以来的时间（r〜2 = 0.11，p <0.05）和居家人数（r〜2 = 0.11-0.43，p <0.05）等参数呈正相关。但是，导致这些关系的原因仍然不清楚。

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