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首页> 外文期刊>Environmental Science & Technology >Mutagenic and Carcinogenic Hazards of Settled House Dust I: Polycyclic Aromatic Hydrocarbon Content and Excess Lifetime Cancer Risk from Preschool Exposure
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Mutagenic and Carcinogenic Hazards of Settled House Dust I: Polycyclic Aromatic Hydrocarbon Content and Excess Lifetime Cancer Risk from Preschool Exposure

机译：居室粉尘的致突变和致癌危险I：多环芳烃含量和学前暴露造成的终身癌症风险

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摘要

Settled house dust (SHD) may be a significant source of children's indoor exposure to hazardous substances including polycyclic aromatic hydrocarbons (PAHs). In this study, organic extracts of sieved vacuum cleaner dust from 51 homes were examined for the presence of 13 PAHs via GC/MS. PAHs were found in all samples with levels of total PAHs ranging between 1.5 and 325 μg g~(-1). The PAH concentrations in the SHD were correlated with information contained in corresponding household questionnaires. Analyses showed levels of PAHs to be negatively associated with noncombustion activities such as vacuum cleaning frequency. A risk assessment was conducted to evaluate the excess lifetime cancer risks posed to preschool aged children who ingested PAHs in SHD. The assessment revealed that exposure to PAHs at levels found in 90% of the homes (< 40 μg g~(-1)) would result in excess cancer risks that are considered acceptable (i.e., 1-100 × 10~(-6)). However, exposure to higher levels of PAHs found in five homes yielded risks that could be higher than 1 × 10~(-4).
机译：居室灰尘（SHD）可能是儿童室内暴露于有害物质（包括多环芳烃（PAH））的重要来源。在这项研究中，通过GC / MS检查了来自51户家庭的经过筛分的真空吸尘器粉尘的有机提取物是否存在13种PAH。在所有样品中都发现了多环芳烃，总多环芳烃的含量在1.5至325μgg〜（-1）之间。 SHD中的PAH浓度与相应的家庭问卷中包含的信息相关。分析表明，PAHs水平与不燃烧活动（如真空清洁频率）负相关。进行了风险评估以评估摄入SHD中PAHs的学龄前儿童的终生癌症风险。评估显示，暴露于90％的家庭中的PAHs（<40μgg（（-1）））会导致被认为可以接受的过量癌症风险（即1-100×10〜（-6）） ）。但是，暴露于五个家庭中较高水平的PAHs所产生的风险可能高于1×10〜（-4）。

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