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首页> 外文期刊>Environmental Science & Technology >Application of Solid-Phase Microextraction for In Vivo Laboratory and Field Sampling of Pharmaceuticals in Fish
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Application of Solid-Phase Microextraction for In Vivo Laboratory and Field Sampling of Pharmaceuticals in Fish

机译：固相微萃取在鱼类体内药物实验室和野外采样中的应用

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Previous field studies utilizing solid-phase microextraction (SPME) predominantly focused on volatile and semivolatile compounds in air or water. Earlier in vivo sampling studies utilizing SPME were limited to the liquid matrix (blood). The present study has expanded the SPME technique to semisolid tissues under laboratory and field conditions through the investigation of both theoretical and applied experimental approaches. Pre-equilibrium extraction and desorption were performed in vivo in two separate animals. Excellent linearity was found between the amounts extracted by SPME from the muscle of living fish and the waterborne concentrations of Pharmaceuticals. A simple SPME method is also described to simultaneously determine free and total analyte concentrations in living tissue. The utility of in vivo SPME sampling was evaluated in wild fish collected from a number of different river locations under varying degrees of influence from municipal wastewater effluents. Diphenhydramine and diltiazem were detected in the muscle of fish downstream of a local wastewater treatment plant. Based on this study, SPME demonstrated several important advantages such as simplicity, sensitivity, and robustness under laboratory and in vivo field sampling conditions.
机译：先前利用固相微萃取（SPME）进行的现场研究主要集中于空气或水中的挥发性和半挥发性化合物。利用SPME进行的早期体内采样研究仅限于液体基质（血液）。通过研究理论和应用实验方法，本研究已将SPME技术扩展到实验室和现场条件下的半固体组织。在两只单独的动物体内进行了平衡前的提取和解吸。在SPME从活鱼的肌肉中提取的量与药物的水性浓度之间发现了极好的线性关系。还介绍了一种简单的SPME方法，可同时测定活组织中的游离和总分析物浓度。体内SPME采样的实用性在市政污水排放的不同程度影响下，对从许多不同河流地区采集的野生鱼类进行了评估。在当地废水处理厂下游的鱼肉中检测到苯海拉明和地尔硫卓。根据这项研究，SPME在实验室和体内野外采样条件下展示了几个重要的优点，例如简单，灵敏和坚固。

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