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首页> 外文期刊>Environmental Science & Technology >Validation of Dietary Intake of Dichlorodiphenyltrichloroethane and Metabolites in Two Populations from Beijing and Shenyang, China Based on the Residuals in Human Milk
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Validation of Dietary Intake of Dichlorodiphenyltrichloroethane and Metabolites in Two Populations from Beijing and Shenyang, China Based on the Residuals in Human Milk

机译：基于人乳中的残留量验证北京和沉阳两个人群饮食中二氯二苯基三氯乙烷和代谢物的摄入量

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摘要

This paper presents the results of an investigation on association between dietary intakes and human milk concentrations of dichlorodiphenyltrichloroethane and metabolites (DDTs) of two populations from Beijing and Shenyang, China. We analyzed human milk samples from 76 women and 287 composite food samples covering major food categories for concentrations of DDTs. We also collected information on food consumptions and calculated dietary intakes of DDTs of the participants on individual basis. The median values of the measured DDTs in human milk were 125 ng/g lipid and 132 ng/g lipid for the samples from Beijing and Shenyang, respectively. The mean (istandard deviation) daily dietary intakes of DDTs by the two groups were 32.0 ± 14.2 ng/kg·day and 27.9 ± 11.3 ng/kg'day, respectively. The temporal trends of decreasing in DDTs and increasing in DDE/DDT ratio suggested that the residuals were primarily from historical application. We found a significant correlation between human milk concentration and daily dietary intake of DDTs, while the dietary intake could explain 22% of the variation in the DDTs in human milk. In addition to dietary exposure, we also found that maternal body mass index (body weight divided by the squared height), body weight, body height and mother's age contributed significantly to the variation of DDTs in human milk after intake normalization. The result of a probabilistic risk assessment indicated that the exposure of infants to DDTs through breast feeding would be a public health concern for years to come, although breast feeding is still recommended.
机译：本文介绍了来自北京和沉阳两个人群的膳食摄入量与母乳中二氯二苯基三氯乙烷和代谢物（DDT）浓度之间的相关性调查结果。我们分析了76种妇女的牛奶样本和287种主要食物类别的复合食品样本中的滴滴涕浓度。我们还收集了有关食品消费的信息，并根据参与者的个人饮食计算了DDT的饮食摄入量。来自北京和沉阳的样品中测得的人乳中滴滴涕的中位数分别为125 ng / g脂质和132 ng / g脂质。两组DDT的日平均饮食摄入量分别为32.0±14.2 ng / kg·天和27.9±11.3 ng / kg·天。 DDTs减少和DDE / DDT比值增加的时间趋势表明，残差主要来自历史应用。我们发现人乳中的DDT含量与人乳中的DDS含量之间存在显着相关性，而饮食中DDT的变化可以解释22％的人乳中DDT的变化。除了饮食外，我们还发现母体体重指数（体重除以身高的平方），体重，身高和母亲的年龄对摄入正常化后母乳中滴滴涕的变化有显着影响。概率风险评估的结果表明，尽管仍建议使用母乳喂养，但今后几年，通过母乳喂养婴儿接触滴滴涕将是公共卫生问题。

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