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首页> 外文期刊>Environmental Science & Technology >Nanoparticulate Vanadium Oxide Potentiated Vanadium Toxicity in Human Lung Cells
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Nanoparticulate Vanadium Oxide Potentiated Vanadium Toxicity in Human Lung Cells

机译：纳米微粒氧化钒对人肺细胞的钒毒性增强

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摘要

Metal oxides may hold, as nanosized particles, a toxic potential to human health and the environment that is not present in the bulk material. Due to the high surface-to-volume ratio, small amounts can lead to strong oxidative damage within biological systems, impairing cellularfunctions as a consequence of their high surface reactivity. We report here on a new nanosized V_2O_3 material that has a needle-like structure with diameters of less than 30 nm and variable lengths. The potentiated toxicity of nanoscale vanadium oxide (V_2O_3) compared to bulk material is demonstrated here in human endo- and epithelial lung cells, and might be due to the higher catalytic surface of the particles. Reduction in cell viability is almost ten times stronger and starts with lowest concentrations of "nanoscaled" material (10 μg/mL). Vanadium oxide leads to an induction of heme oxygenase 1 (HO-1) in a dose dependent manner in ECV304 cells whereas a reduction in protein levels can be observed for the epithelial cells (A549). Lipid peroxidation can be observed also for "nanoscaled" vanadium oxide to a much stronger extent in macrophages (RAW cells) than for bulk material. The observed effects can not only be explained by oxidation from V_2O_3 to V_2O_5 as there are significant differences between the novel nano vanadium and all used bulk materials (V_2O_3 and V_2O_5). It appears rather to be a nanoeffect of a high surface reactivity, here coupled with a yet unknown toxicity potentiating effect of a technically important catalyst.
机译：金属氧化物可能会以纳米级颗粒的形式保留对人体健康和环境的潜在毒性，而这种潜在毒性是散装材料中不存在的。由于高的表面体积比，少量的生物表面会导致强烈的氧化损伤，由于其高的表面反应性而损害细胞功能。我们在这里报告了一种新型的纳米级V_2O_3材料，该材料具有直径小于30 nm且长度可变的针状结构。与散装材料相比，纳米氧化钒（V_2O_3）的增强毒性在人的上皮和上皮肺细胞中得到证实，这可能是由于颗粒的催化表面较高所致。细胞活力降低的强度几乎是原来的十倍，并且始于最低浓度的“纳米级”材料（10μg/ mL）。氧化钒在ECV304细胞中以剂量依赖的方式导致血红素加氧酶1（HO-1）的诱导，而上皮细胞（A549）则可观察到蛋白质水平的降低。在巨噬细胞（RAW细胞）中，“纳米级”氧化钒的脂质过氧化作用也要比散装材料强得多。观察到的效果不仅可以通过从V_2O_3氧化为V_2O_5来解释，因为新型纳米钒与所有使用的块状材料（V_2O_3和V_2O_5）之间都存在显着差异。它似乎是高表面反应性的纳米效应，在这里与技术上重要的催化剂的未知的毒性增强作用相结合。

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