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首页> 外文期刊>Environmental Science & Technology >Toxicogenomic Response to Chlorination Includes Induction of Major Virulence Genes in Staphylococcus aureus
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Toxicogenomic Response to Chlorination Includes Induction of Major Virulence Genes in Staphylococcus aureus

机译：氯化毒理基因组学响应包括金黄色葡萄球菌中主要毒力基因的诱导。

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摘要

Despite the widespread use of chlorination for microbial control in aqueous environments, cellular response mechanisms of human pathogens, such as Staphylococcus aureus, against chlorination remain unknown. In this work, genome-wide transcriptional analysis was performed to elucidate cellular response of S. aureus to hypochlorous acid, an active antimicrobial product of chlorination in aqueous solution. Our results suggest that hypochlorous acid repressed transcription of genes involved in cell wall synthesis, membrane transport, protein synthesis, and primary metabolism, while amino acid synthesis genes were induced. Furthermore, hypochlorous acid induced transcription of genes encoding major virulence factors of S. aureus, such as exotoxins, hemoiysins, leukocidins, coagulases, and surface adhesion proteins, which all play essential roles in staphylococcal virulence.
机译：尽管在水环境中氯化广泛用于微生物控制，但是人类病原体例如金黄色葡萄球菌对氯化的细胞应答机制仍然未知。在这项工作中，进行了全基因组转录分析，以阐明金黄色葡萄球菌对次氯酸的细胞反应，次氯酸是水溶液中氯化的活性抗菌产物。我们的结果表明，次氯酸抑制了涉及细胞壁合成，膜转运，蛋白质合成和初级代谢的基因的转录，而诱导了氨基酸合成基因。此外，次氯酸诱导了编码金黄色葡萄球菌主要毒力因子的基因的转录，例如外毒素，血红素，白血球菌素，凝固酶和表面粘附蛋白，它们在葡萄球菌毒力中均起重要作用。

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