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首页> 外文期刊>Environmental Science & Technology >Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish
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Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish

机译：抗甲状腺药物丙基硫氧嘧啶在斑马鱼部分生命周期测定中的作用

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摘要

Some ubiquitous pollutants of the aquatic environment, such as PCBs or other polyhalogenated aromatic hydrocarbons, may disrupt the thyroid hormone system. In a partial life cycle assay with zebrafish (Danio rerio), we studied the effects of the reference compound propylthiouracil (PTU) on reproduction, growth and development, histopathology of some target tissues, and plasma thyroid hormone levels. PTU induced a concentration-dependent increase of egg production with a concomitant decrease of mature oocyte size but had no effect on fertilization rate or hatching. In F1, serious dysmorphogenesis was found in 4 dph larvae at the highest PTU level tested (100 mg/L), and there was a dose-dependent decrease in body length and weight at 42 dph (significant at 100 mg/L PTU). At this time, there was also a decreased scale thickness, suggesting inhibited metamorphosis, detectable at 1 mg/L PTU and higher. PTU also induced activation of the thyroid follicles in a concentration-dependent way, in juveniles associated with hyperemia in the thyroid area, and depletion of liver glycogen. Effects in adults were associated with decreased circulating levels of the thyroid hormones T-3 and T-4. These observations indicate that disruption of the thyroid hormone system may affect the fitness of these aquatic organisms. The zebrafish model may contribute to the identification of thyroid hormone disrupting activity in water samples and also in the interpretation of histological observations in free-ranging fish species.
机译：一些水生环境中普遍存在的污染物，例如多氯联苯或其他多卤代芳烃，可能会破坏甲状腺激素系统。在斑马鱼（Danio rerio）的部分生命周期分析中，我们研究了参考化合物丙基硫氧嘧啶（PTU）对生殖，生长和发育，某些目标组织的组织病理学以及血浆甲状腺激素水平的影响。 PTU诱导卵子产生浓度依赖性的增加，同时卵母细胞的成熟度降低，但对受精率或孵化率没有影响。在F1中，在测试的最高PTU水平（100 mg / L）下，在4 dph幼虫中发现了严重的畸形发生，并且在42 dph时，体重和体重呈剂量依赖性下降（在100 mg / L PTU时显着）。此时，鳞片厚度也减小，表明抑制了变态，在1 mg / L PTU或更高时可检测到。在与甲状腺充血和肝糖原耗竭有关的青少年中，PTU还以浓度依赖的方式诱导甲状腺滤泡的活化。对成年人的影响与甲状腺激素T-3和T-4的循环水平降低有关。这些观察结果表明甲状腺激素系统的破坏可能影响这些水生生物的适应性。斑马鱼模型可能有助于识别水样中的甲状腺激素破坏活性，也有助于解释自由放养鱼类的组织学观察结果。

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