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首页> 外文期刊>Environmental Science & Technology >Oral exposure of PBDE-47 in fish: Toxicokinetics and reproductive effects in Japanese medaka (Oryzias latipes) and fathead minnows (Pimephales promelas)
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Oral exposure of PBDE-47 in fish: Toxicokinetics and reproductive effects in Japanese medaka (Oryzias latipes) and fathead minnows (Pimephales promelas)

机译：鱼类中PBDE-47的口服暴露：日本（Oryzias latipes）和黑头min（Pimephales promelas）的毒代动力学和生殖效应

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摘要

The toxicokinetics of 2,2,4,4-tetrabromodiphenyl other (PBDE-47) was studied in the Japanese Medaka (Oryzias latipes) after a single oral exposure followed by termination at specific time points. The effects of repeated oral exposure to PBDE-47 on reproductive performance was assessed using a pair breeding experimental design with fathead minnows (Pimephales promelas) given daily PBDE-47 exposures for 25 days, during which fecundity was measured as an indicator of reproductive performance. Medaka and fathead minnows were orally exposed to PBDE47 by bioencapsulation in brine shrimp, Artemia sp. In the medaka studies, measurable levels of PBDE-47 were detected in the carcass within 0.25 h with peak levels occurring at 8 h. The body levels of PBDE-47 slowly declined and were still 25% of peaklevels at 624h after dosing. Assimilation of the bioencapsulated dose was at least 80% and may well approach 100%. The PBDE-47 concentration-time profile was fitted to a one-compartment clearance-volume toxicokinetic model and the model-predicted value for elimination half-life was determined to be 281 h and the first-order absorption rate constant was K-a = 0.26 hr(-1). In the fathead minnow study, egg laying in the PBDE-treated breeding pairs stopped after 10 days. The condition factor of PBDE-treated males was significantly reduced (P < 0.011) compared with control males, whereas no significant difference was observed in females. Histological examination revealed a greater than 50% reduction in mature sperm in PBDE-47 exposed minnows compared to controls. Collectively, these results suggest PBDE-47 is selectively toxic to sexually mature male fathead minnows.
机译：在日本Medaka（Oryzias latipes）中研究了2,2,4,4-四溴二苯其他（PBDE-47）的毒物代谢动力学，单次口服暴露后在特定时间点终止。使用成对繁殖实验设计评估反复口服PBDE-47对生殖能力的影响，该对实验设计的头是head鱼（Pimephales promelas），每天暴露PBDE-47持续25天，在此期间将繁殖力作为生殖性能的指标。通过在盐水虾Artemia sp。中的生物封装将Medaka和黑头min鱼口服暴露于PBDE47。在medaka研究中，在cas体中在0.25 h内检测到可测量的PBDE-47水平，在8 h达到峰值。给药后624h，PBDE-47的体内水平缓慢下降，仍为峰值水平的25％。生物封装剂量的同化率至少为80％，很可能接近100％。将PBDE-47浓度-时间曲线拟合到单室清除体积毒物动力学模型，消除半衰期的模型预测值确定为281 h，一阶吸收速率常数为Ka = 0.26 hr （-1）。在the头min鱼研究中，经过PBDE处理的繁殖对中的卵在10天后停止繁殖。与对照雄性相比，PBDE治疗的雄性的条件因子显着降低（P <0.011），而雌性则没有显着差异。组织学检查显示，与对照组相比，暴露于PBDE-47的小鱼的成熟精子减少了50％以上。总的来说，这些结果表明PBDE-47对性成熟的雄性黑头min鱼有选择性的毒性。

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