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Temporal Dynamics of Effect Concentrations

机译：效应浓度的时间动态

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摘要

In effect assessment the comparability and applicability of LCx and ECx values,which are calculated at single points in time during exposure,relies on the ability to perform a valid extrapolation to other time points of interest.The behavior of LCx in time has been extensively studied,and the behavior of ECx in time is expected to follow similar dynamics,as it is considered that the LCx is just a specific case of ECxs.However,most models have focused on validating the dynamics of LCx,and hardly anything is known about the time dependence of ECx for other endpoints or whether it is comparable to that of LCxs.We have created four scenarios where we study the dynamics of the ECx for different endpoints and how it is affected by the characteristics of two different compounds (carbendazim and pentachlorobenzene) and of two different life history strategies (hermaphroditic and sexually reproducing strains of Caenorhabditis elegans).The observed patterns of behavior in time of the ECx for body size and for reproduction showed unexpected dynamics that deviate considerably from that of the LCx.It was demonstrated that the temporal dynamics of ECx were very different for each particular endpoint.The shape of the ECx-time curves depends on the intrinsic characteristics of the endpoint of study,as well as on the characteristics of the compound and life history strategy of the organism.This makes extrapolation in time or between endpoints difficult and hampers the comparability of results based on this summary statistic.The interpretation of the results from toxicity tests can be improved through process-based modeling,as demonstrated on the current data set.
机译：在效果评估中，在曝光过程中的单个时间点计算出的LCx和ECx值的可比性和适用性依赖于对其他感兴趣的时间点进行有效推断的能力。 ，而且据认为LCx只是ECx的一种特殊情况，因此ECx的及时行为也将遵循类似的动态。然而，大多数模型都集中在验证LCx的动态上，几乎没有关于ECx的任何信息。 ECx对其他端点的时间依赖性或与LCx的可比性我们创建了四个方案，研究了不同端点的ECx动力学以及两种不同化合物（多菌灵和五氯苯）的特性对ECx的影响以及两种不同的生活史策略（秀丽隐杆线虫的雌雄同体和有性生殖的菌株）。 y的大小和繁殖表现出意想不到的动态，与LCx的动态有很大出入。事实证明，每个特定端点ECx的时间动态都非常不同.ECx时间曲线的形状取决于端点的内在特性研究，以及该生物的化合物的特性和生命史策略。这使得在时间上或在端点之间进行外推变得困难，并且阻碍了基于该摘要统计数据的结果可比性。毒性测试结果的解释可以如当前数据集所示，可以通过基于过程的建模进行改进。

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  • 来源
    《Environmental Science & Technology》 |2006年第7期|p.2478-2484|共7页
  • 作者

    OLGA ALDA ALVAREZ; TJALLING JAGER; BEATRIZ NUNEZCOLAO; JAN E.KAMMENGA;

  • 作者单位

    Laboratory of Nematology,Wageningen University,Binnenhaven 5,6709 PD Wageningen,The Netherlands;

    Department of Theoretical Biology,Vrije Universiteit,de Boelelaan 1085,NL-1081 HV,Amsterdam,The Netherlands;

    Laboratory of Nematology,Wageningen University,Binnenhaven 5,6709 PD Wageningen,The Netherlands;

    Department of Theoretical Biology,Vrije Universiteit,de Boelelaan 1085,NL-1081 HV,Amsterdam,The Netherlands;

    Laboratory of Nematology,Wageningen University,Binnenhaven 5,6709 PD Wageningen,The Netherlands;

    Department of Theoretical Biology,Vrije Universiteit,de Boelelaan 1085,NL-1081 HV,Amsterdam,The Netherlands;

    Laboratory of Nematology,Wageningen University,Binnenhaven 5,6709 PD Wageningen,The Netherlands;

    Department of Theoretical Biology,Vrije Universiteit,de Boelelaan 1085,NL-1081 HV,Amsterdam,The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 环境化学;
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