• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Distribution of chiral PCBs in selected tissues in the laboratory rat
【24h】

Distribution of chiral PCBs in selected tissues in the laboratory rat

机译：手性多氯联苯在实验大鼠选定组织中的分布

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The enantiomeric enrichment of polychlorinated biphenyl (PCB) atropisomers has been reported in both wildlife and in humans. The biological processes causing this enrichment are only poorly investigated, a fact that limits the use of enantiomeric fractions (EFs) as a tool to study various processes of environmental relevance. To further understand these enantioselective processes, this study investigates the tissue distribution and EFs of some PCB atropisomers after administration of PCB mixtures to immature male Sprague-Dawley rats. The mixtures selected for this study, Aroclor 1254 and an environmental mixture extracted from Chlorofen-contaminated soil, are qualitatively different and are known to induce different groups of hepatic enzymes. Animals were sacrificed 6 days after dosing, PCBs were extracted, and, whenever possible, the EFs of PCBs 84, 91, 95, 149, 174, and 176 were determined by chiral gas chromatography. The EFs of PCB 95 ( adipose tissue, liver, and skin) and PCB 149 (adipose tissue, liver, skin, and blood) in tissues from Aroclor 1254-treated animals differed significantly from EFs in the Aroclor standard, while only EFs of PCB 95 (blood) and PCB 174 (adipose tissue) in tissues from soil-extract-treated animals were different from those of the Chlorofen soil extract. PCB 149 in tissues from soil-extract-treated animals underwent no statistically significant enantiomeric enrichment. These differences in the EFs clearly suggest that the enantioselective enrichment of PCB atropisomers may correlate with exposure history, and with the induction of hepatic enzymes, and that EFs may be useful chemical markers of physiologic and biochemical changes following exposure to PCBs.
机译：在野生动植物和人类中都已经报道了多氯联苯（PCB）阻转异构体的对映体富集。导致这种富集的生物学过程仅进行了很少的研究，这一事实限制了对映体级分（EFs）作为研究各种与环境相关的过程的工具的使用。为了进一步了解这些对映选择性过程，本研究调查了将PCB混合物施用于未成熟的雄性Sprague-Dawley大鼠后，某些PCB阻转异构体的组织分布和EF。在本研究中选择的混合物Aroclor 1254和从受氯氟芬污染的土壤中提取的环境混合物在质量上有所不同，并且已知会诱导不同种类的肝酶。给药后6天处死动物，提取PCBs，并尽可能通过手性气相色谱法测定PCBs 84、91、95、149、174和176的EF。 Aroclor 1254处理过的动物组织中的PCB 95（脂肪组织，肝脏和皮肤）和PCB 149（脂肪组织，肝脏，皮肤和血液）的EF与Aroclor标准中的EF显着不同，而只有PCB的EF土壤提取物处理过的动物组织中的95（血液）和PCB 174（脂肪组织）与氯叶芬土壤提取物的组织不同。来自土壤提取物处理过的动物的组织中的PCB 149没有进行统计上显着的对映体富集。 EF中的这些差异清楚地表明，PCB阻转异构体的对映选择性富集可能与接触历史以及与肝酶的诱导有关，并且EF可能是接触PCB后生理和生化变化的有用化学标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号