...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Technology >Production of polyhydroxyalkanoates (PHA) using sludge from different wastewater treatment processes and the potential for medical and pharmaceutical applications
【24h】

Production of polyhydroxyalkanoates (PHA) using sludge from different wastewater treatment processes and the potential for medical and pharmaceutical applications

机译：使用来自不同废水处理工艺的污泥生产聚羟基链烷酸酯（PHA），以及在医疗和制药领域的潜力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, seven strains of bacteria with polyhydroxyalkanoates (PHA)-producing ability (i.e. Bacillus cereus, Pseudomonas putida, Bacillus pumilus, Pseudomona huttiensis, Yersinia frederiksenii, Aeromonas ichthiosmia, and Sphingopyxis terrae) were isolated from various waste treatment plants in Hong Kong. Simultaneous wastewater treatment and PHA accumulation were successfully achieved in the bioreactors using isolated bacteria from different sludges. At the organic loading less than 13,000 ppm, more than 95% of chemical oxygen demand (COD) was removed by the isolated strains before the decrease of PHA accumulation. In addition, more than 95% of nitrogen removal was achieved by all isolated strains. In the bioreactors inoculated with single strains, the highest yields of poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxyvalerate) (PHV) were obtained in A. ichthiosmia (84 mg PHB/g) and B. cereus (69 mg/g), respectively. For the mixed culture, the highest yields of PHB and PHV were increased by 55% and 45% in the system inoculated with B. pumilus and A. ichthiosmia. The biologically synthesized PHA also showed the potential applications in drug delivery and tissue engineering. PHA-nanoparticles loaded with pyrene were successfully prepared by recombinant Escherichia coli. The results of in vitro drug release and biocompatibility tests revealed that nanoparticles could be used as safer dray carriers with high loading capacity and efficiency. After 20 days, the cells successfully grew on 90% of the PHA-aortic valve.
机译：在本研究中，从香港的各种废物处理厂中分离出了七种具有多羟基链烷酸酯（PHA）产生能力的细菌菌株（即蜡状芽孢杆菌，恶臭假单胞菌，短小芽孢杆菌，赫氏假单胞菌，弗氏耶尔森氏菌，鱼腥藻气单胞菌和地衣藻）。 。使用来自不同污泥的分离细菌，在生物反应器中成功实现了同时废水处理和PHA积累。在有机物负载量低于13,000 ppm时，在PHA积累减少之前，分离出的菌株去除了超过95％的化学需氧量（COD）。此外，所有分离的菌株均实现了95％以上的脱氮。在用单株接种的生物反应器中，在鱼鳞曲霉菌（84 mg PHB / g）和蜡状芽孢杆菌（69）中获得了最高的聚3-羟基丁酸酯（PHB）和聚3-羟基戊酸酯（PHV）产量。毫克/克）。对于混合培养，接种短小芽孢杆菌和鱼鳞曲霉的系统中，PHB和PHV的最高产量分别提高了55％和45％。生物合成的PHA还显示了在药物输送和组织工程中的潜在应用。重组大肠杆菌成功制备了负载pyr的PHA纳米颗粒。体外药物释放和生物相容性测试的结果表明，纳米颗粒可以用作具有较高载量和效率的更安全的托盘载体。 20天后，细胞可在90％的PHA主动脉瓣上成功生长。

著录项

  • 来源
    《Environmental Technology》 |2017年第16期|1779-1791|共13页
  • 作者

    Lam Wai; Wang Yujie; Chan Pui Ling; Chan Shun Wan; Tsang Yiu Fai; Chua Hong; Yu Peter Hoi Fu;

  • 作者单位

    SGS Hong Kong Ltd, Hong Kong, Hong Kong, Peoples R China;

    Guangdong Univ Technol, Fac Environm Sci & Engn, Guangzhou, Guangdong, Peoples R China;

    Sch Higher & Profess Educ Chai Wan, Dept Appl Sci, Chaiwan, Hong Kong, Peoples R China;

    Technol & Higher Educ Inst Hong Kong, Fac Sci & Technol, Tsing Yi, Hong Kong, Peoples R China;

    Educ Univ Hong Kong, Dept Sci & Environm Studies, Tai Po, Hong Kong, Peoples R China|Guizhou Acad Sci, Guiyang 550001, Guizhou, Peoples R China;

    Technol & Higher Educ Inst Hong Kong, Fac Sci & Technol, Tsing Yi, Hong Kong, Peoples R China;

    Technol & Higher Educ Inst Hong Kong, Fac Sci & Technol, Tsing Yi, Hong Kong, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Bioplastic; sequencing batch reactor; mixed microbial culture; drug delivery; tissue engineering;

    机译：生物塑料;测序间歇反应器;混合微生物培养;药物输送;组织工程;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号