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首页> 外文期刊>Environmental toxicology and pharmacology >Sodium tanshinone IIA sulfonate attenuates silica-induced pulmonary fibrosis in rats via activation of the Nrf2 and thioredoxin system
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Sodium tanshinone IIA sulfonate attenuates silica-induced pulmonary fibrosis in rats via activation of the Nrf2 and thioredoxin system

机译：丹参酮IIA磺酸钠通过NRF2和硫辛素系统的激活衰减大鼠大鼠肺纤维化

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摘要

Silicosis is characterized by pulmonary fibrosis due to long-term inhalation of silica particles. Although the cause of this serious disease is known, its pathogenesis remains unclear and there are currently no specific treatments. Recent studies have shown that the anti-oxidant transcription factor Nrf2 is expressed at reduced levels in fibrotic foci, which may be related to disease progression. However, the molecular mechanisms by which this might occur have yet to be elucidated. Sodium tanshinone IIA sulfonate (STS), an extract of Salvia miltiorrhiza, is used in traditional Chinese medicine in the treatment of coronary heart disease. STS has been shown to play a strong anti-oxidative role in various organs. Here, we employed a rat model to explore the effects of STS on oxidative stress and the progression of fibrosis in silicosis. STS significantly reduced collagen deposition in the lungs, thereby antagonising silicosis. Immunohistochemical and immunofluorescence staining showed that Nrf2 was differentially expressed in lung cells during silica induced fibrosis, and chromatin immunoprecipitation-sequencing experiments demonstrated that Nrf2 promoted the expression of the antioxidant proteins thioredoxin and thioredoxin reductase. Our results suggest that the anti-fibrotic effects of STS may be related to upregulation of Nrf2 nuclear expression, especially in fibrotic lesions, and the promotion of thioredoxin and thioredoxin reductase expression. Our findings may open up new avenues for the development of STS as a treatment for silicosis.
机译：由于长期吸入二氧化硅颗粒，矽肺病的特征在于肺纤维化。虽然这种严重疾病的原因是已知的，但其发病机制仍然尚不清楚，目前没有具体的治疗方法。最近的研究表明，抗氧化转录因子NRF2在纤维化焦点的降低水平下表达，这可能与疾病进展有关。然而，可能发生这种情况的分子机制尚未阐明。丹参酮IIA磺酸钠（STS）是丹参的提取物，用于中医治疗冠心病的治疗。 STS已被证明在各种器官中发挥着强烈的抗氧化作用。在这里，我们采用了大鼠模型来探讨STS对硅化纤维化的氧化应激和纤维化进展的影响。 STS显着降低了肺部胶原沉积，从而拮抗矽肺病。免疫组织化学和免疫荧光染色表明，在二氧化硅诱导的纤维化期间，NRF2在肺细胞中差异表达，染色质免疫沉淀序列测定实验证明NRF2促进了抗氧化蛋白硫素和硫辛素还原酶的表达。我们的研究结果表明，STS的抗纤维化效应可能与NRF2核表达的上调相关，特别是在纤维化病变中，以及促进毒素和肝素还原酶表达的促进。我们的调查结果可能会为STS开发的新途径作为矽肺病的治疗。

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  • 来源
    《Environmental toxicology and pharmacology》 |2020年第11期|103461.1-103461.8|共8页
  • 作者

    Zhonghui Zhu; Qiuyue Li; Chunjie Xu; Jing Zhao; Siling Li; Yan Wang; Lin Tian;

  • 作者单位

    Department of Occupational and Environmental Health School of Public Health Capital Medical University Beijing 100069 China Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing 100069 China;

    Department of Occupational and Environmental Health School of Public Health Capital Medical University Beijing 100069 China Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing 100069 China;

    Department of Occupational and Environmental Health School of Public Health Capital Medical University Beijing 100069 China Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing 100069 China;

    Department of Occupational and Environmental Health School of Public Health Capital Medical University Beijing 100069 China Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing 100069 China;

    Department of Occupational and Environmental Health School of Public Health Capital Medical University Beijing 100069 China Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing 100069 China;

    Department of Occupational and Environmental Health School of Public Health Capital Medical University Beijing 100069 China Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing 100069 China;

    Department of Occupational and Environmental Health School of Public Health Capital Medical University Beijing 100069 China Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing 100069 China;

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  • 正文语种 eng
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  • 关键词

    Nrf2; Trx; Silicosis; Sodium tanshinone IIA sulfonate;

    机译：NRF2;trx;矽肺;丹参酮钠Iia磺酸钠;

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