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首页> 外文期刊>Environmental toxicology and chemistry >Mixture toxicity of copper, cadmium, and zinc to barley seedlings is not explained by antioxidant and oxidative stress biomarkers
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Mixture toxicity of copper, cadmium, and zinc to barley seedlings is not explained by antioxidant and oxidative stress biomarkers

机译：抗氧化剂和氧化应激生物标志物不能解释铜，镉和锌对大麦幼苗的混合毒性

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The analysis of metal mixture toxicity to plants is complicated by mutual interactions. In the present study, mixture effects of zinc (Zn), cadmium (Cd), and copper (Cu) on barley (Hordeum vulgare L.) root elongation were analyzed using oxidative stress parameters. The hypothesis was that toxic mixture effects on plant growth are better explained by biochemical parameters than by exposure information, because the former excludes interactions among metals for root uptake. Barley seedlings were exposed for 5d or 14d to these metals in nutrient solutions, added in isolation and as mixtures. Root elongation in Cu+Cd mixtures was well predicted from free metal ion concentrations in solution, using concentration addition (CA) or independent action (IA) reference models. In contrast, Zn acted antagonistically when combined with Cu and/or Cd, relative to both CA and IA. This protective effect of Zn correlated with the biomarkers measured in the long-term experiment; oxidative stress (indicated by malondialdehyde level, for example) decreased after addition of Zn. In addition, it was found that some biomarkers were sensitive to both Cu and Cd dosed in isolation, but not to Cu+Cd mixtures. Overall, the exposure explained mixture effects better than most of the 16 measured biomarkers (i.e., the biochemical effects). It is concluded that these biomarkers are not robust indicators for metal mixture toxicity, potentially because different metals have different parallel modes of action on growth that are insufficiently indexed by the biomarkers. Environ Toxicol Chem 2017;36:220-230. (c) 2016 SETAC
机译：金属混合物对植物的毒性分析由于相互影响而变得复杂。在本研究中，使用氧化应激参数分析了锌（Zn），镉（Cd）和铜（Cu）对大麦（Hordeum vulgare L.）根伸长的混合效应。假设是，通过生化参数比通过暴露信息更好地解释了有毒混合物对植物生长的影响，因为前者排除了金属之间因根吸收而产生的相互作用。将大麦幼苗暴露于营养液中的这些金属中5d或14d，并单独添加或混合添加。使用浓度添加（CA）或独立作用（IA）参考模型，可以根据溶液中的游离金属离子浓度很好地预测Cu + Cd混合物中的根伸长。相反，相对于CA和IA，Zn与Cu和/或Cd结合时具有拮抗作用。锌的这种保护作用与长期实验中测得的生物标志物有关。添加锌后，氧化应激（例如，以丙二醛水平表示）降低。另外，发现一些生物标志物对分离施用的Cu和Cd均敏感，但对Cu + Cd混合物不敏感。总体而言，暴露解释了混合物的效果要优于16种已测生物标志物中的大多数（即生化效应）。结论是这些生物标志物不是金属混合物毒性的可靠指标，这可能是因为不同的金属对生长具有不同的平行作用方式，而这些生物标志物不足以对其进行索引。 Environ Toxicol Chem 2017; 36：220-230。 （c）2016年SETAC

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