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首页> 外文期刊>Environmental toxicology and chemistry >REPRODUCTIVE EFFECTS ON FRESHWATER FISH EXPOSED TO 17 alpha-TRENBOLONE AND 17 alpha-ESTRADIOL
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REPRODUCTIVE EFFECTS ON FRESHWATER FISH EXPOSED TO 17 alpha-TRENBOLONE AND 17 alpha-ESTRADIOL

机译：暴露于17α-戊二酮和17α-雌二醇的淡水鱼的繁殖效应

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17 alpha-Trenbolone and 17 alpha-estradiol are principal metabolites in cattle excreta following the administration of Synovex (R) ONE, which contains trenbolone acetate and estradiol benzoate. As part of the environmental assessment of the use of Synovex (R) ONE, data were generated to characterize the effects of 17 alpha-trenbolone and 17 alpha-estradiol on the reproduction of freshwater fish. These substances are known endocrine disruptors, so the purpose of testing was not to clarify these properties but to identify concentrations representing population-relevant effects for use in risk characterization. The short-term reproduction assay was conducted with 17 alpha-trenbolone using the fathead minnow (Pimephales promelas) and the medaka (Oryzias latipes) and with 17 alpha-estradiol using the fathead minnow. Adverse effects on the population-relevant endpoints of survival and fecundity were used to establish the no-observed-effect concentration (NOEC) and the lowest-observed-effect concentration (LOEC) for each study. For 17 alpha-trenbolone, adverse effects on fecundity of the fathead minnow occurred at 120 ng/L; this was the LOEC, and the NOEC was 35 ng/L. 17 beta-Trenbolone did not adversely affect survival and fecundity of medaka at the concentrations tested, resulting in a NOEC of 110 ng/L and a LOEC of > 110 ng/L. 17 alpha-Estradiol did not adversely impact survival and fecundity of the fathead minnow at the concentrations tested, resulting in a NOEC and LOEC of 250 ng/L and > 250 ng/L, respectively. (C) 2016 SETAC
机译：施用Synovex®ONE后，牛群的主要代谢产物是17α-群勃龙和17α-雌二醇，其中含有醋酸群勃龙和苯甲酸雌二醇。作为使用Synovex（R）ONE的环境评估的一部分，已生成数据来表征17α-群勃龙和17α-雌二醇对淡水鱼繁殖的影响。这些物质是已知的内分泌干扰物，因此测试的目的不是澄清这些特性，而是确定代表人群相关效应的浓度以用于风险表征。短期繁殖测定法是使用head头alpha鱼（Pimephales promelas）和the（Oryzias latipes）用17α-群勃龙和用the头min鱼与17α-雌二醇进行的。通过对人群的生存和生育力相关终点的不利影响来确定每项研究的无观察力浓度（NOEC）和最低观察浓度（LOEC）。对于17α-群勃龙，对黑头now鱼繁殖力的不利影响发生在120 ng / L处。这是LOEC，而NOEC是35 ng / L。 17β-群勃龙在所测试的浓度下不会对medaka的存活和繁殖力产生不利影响，其NOEC为110​​ ng / L，LOEC> 110 ng / L。 17α-雌二醇在测试浓度下不会对the鱼的存活和繁殖能力产生不利影响，导致NOEC和LOEC分别为250 ng / L和> 250 ng / L。 （C）2016年SETAC

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