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首页> 外文期刊>Environmental toxicology and chemistry >SPECIES-SPECIFIC AND STRUCTURE-DEPENDENT DEBROMINATION OF POLYBROMINATED DIPHENYL ETHER IN FISH BY IN VITRO HEPATIC METABOLISM
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SPECIES-SPECIFIC AND STRUCTURE-DEPENDENT DEBROMINATION OF POLYBROMINATED DIPHENYL ETHER IN FISH BY IN VITRO HEPATIC METABOLISM

机译：鱼体内多溴二苯醚的物种特异性和结构依赖性脱溴

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摘要

To explore the cause of species-specific differences and structure-activity relationships in the debromination of polybrominated diphenyl ethers (PBDEs) in fish, a series of in vitro measurements of hepatic metabolism of PBDE were made using crucian carp (Carassius carassius) and catfish (Silurus asotus) and the activity of deiodinase in liver microsomes was measured. Debromination was observed in the crucian carp but not in the catfish. No difference was found in total deiodinase activity despite the activity of type 1 deiodinase in crucian carp being twice that of catfish. It is difficult to determine whether the differences in deiodinase activity were responsible for the species-specific differences observed. In crucian carp, penta-brominated diphenyl ether congeners exhibited the highest debromination rates, and the transformation rate decreased with an increasing number of substituted bromines. Adjacent bromine substitution in the phenyl ring was a necessary, but insufficient, condition for debromination in crucian carp. Doubly flanked bromine was always preferentially removed, while single-flanked bromine, meta-substituted bromine, was debrominated the most, followed by para- and then ortho-bromine. No debromination was observed for single-flanked bromine when there was a symmetrical structure with (2, 4, 6) bromine substitutions in 1 phenyl ring, indicating that this structure can improve resistance to debromination metabolism. (C) 2017 SETAC
机译：为了探究鱼类中多溴二苯醚（PBDEs）脱溴过程中物种特异性差异和结构活性关系的原因，使用cru鱼（Carassius carassius）和cat鱼（PB）对PBDE的肝脏代谢进行了一系列体外测量测定了Silurus asotus）和肝微粒体中脱碘酶的活性。在the鱼中观察到脱溴，但在the鱼中未观察到。尽管cru鱼中1型脱碘酶的活性是cat鱼的两倍，但总脱碘酶的活性没有发现差异。很难确定脱碘酶活性的差异是否是所观察到的物种特异性差异的原因。在cru鱼中，五溴代二苯醚同源物的脱溴率最高，并且随着取代溴数量的增加，转化率降低。苯环中溴的相邻取代是cru鱼脱溴的必要条件，但不足。总是优先去除双侧溴，而最大侧脱溴是单侧溴，即间位取代的溴，其次是对溴，然后是邻溴。当在1个苯环中具有（2、4、6）个溴取代的对称结构时，未观察到单侧溴的脱溴，这表明该结构可提高对脱溴代谢的抵抗力。 （C）2017年SETAC

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  • 来源
    《Environmental toxicology and chemistry》 |2017年第8期|1-14|共14页
  • 作者

    Luo Yuan-Lai; Luo Xiao-Jun; Ye Mei-Xia; Zeng Yan-Hong; Chen She-Jun; Mai Bi-Xian;

  • 作者单位

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China|Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Resources Utilizat & P, Guangzhou, Guangdong, Peoples R China|Univ Chinese Acad Sci, Beijing, Peoples R China;

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China|Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Resources Utilizat & P, Guangzhou, Guangdong, Peoples R China;

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China|Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Resources Utilizat & P, Guangzhou, Guangdong, Peoples R China|Univ Chinese Acad Sci, Beijing, Peoples R China;

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China|Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Resources Utilizat & P, Guangzhou, Guangdong, Peoples R China;

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China|Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Resources Utilizat & P, Guangzhou, Guangdong, Peoples R China;

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China|Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Resources Utilizat & P, Guangzhou, Guangdong, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Debromination; Polybrominated diphenyl ether; Structure; Fish liver microsome; Deiodinase;

    机译：脱溴;多溴联苯醚;结构;鱼肝微粒体;脱碘酶;

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