...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >BRAIN REGION DISTRIBUTION AND PATTERNS OF BIOACCUMULATIVE PERFLUOROALKYL CARBOXYLATES AND SULFONATES IN EAST GREENLAND POLAR BEARS (URSUS MARITIMUS)
【24h】

BRAIN REGION DISTRIBUTION AND PATTERNS OF BIOACCUMULATIVE PERFLUOROALKYL CARBOXYLATES AND SULFONATES IN EAST GREENLAND POLAR BEARS (URSUS MARITIMUS)

机译：东格陵兰北极熊（熊熊）的生物累积性全氟烷基羧酸盐和硫磺的脑区分布和模式

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study investigated the comparative accumulation of perfluoroalkyl acids (PFAAs) in eight brain regions of polar bears (Ursus maritimus, n = 19) collected in 2006 from Scoresby Sound, East Greenland. The PFAAs studied were perfluoroalkyl carboxylates (PFCAs, C_6-C_15 chain lengths) and sulfonates (C_4, C_6, C_8, and C_10 chain lengths) as well as selected precursors including perfluorooctane sulfonamide. On a wet-weight basis, blood-brain barrier transport of PFAAs occurred for all brain regions, although inner regions of the brain closer to incoming blood flow (pons/medulla, thalamus, and hypothalamus) contained consistently higher PFAA concentrations compared to outer brain regions (cerebellum, striatum, and frontal, occipital, and temporal cortices). For pons/medulla, thalamus, and hypothalamus, the most concentrated PFAAs were perfluorooctane sulfonate (PFOS), ranging from 47 to 58 ng/g wet weight, and perfluorotridecanoic acid, ranging from 43 to 49 ng/g wet weight. However, PFOS and the longer-chain PFCAs (C_10-C_15) were significantly (p < 0.002) positively correlated with lipid content for all brain regions. Lipid-normalized PFOS and PFCA (C_10-C_15) concentrations were not significantly (p > 0.05) different among brain regions. The burden of the sum of PFCAs, perfluoroalkyl sulfonates, and perfluorooctane sulfonamide in the brain (average mass, 392 g) was estimated to be 46μg. The present study demonstrates that both PFCAs and perfluoroalkyl sulfonates cross the blood-brain barrier in polar bears and that wet-weight concentrations are brain region-specific. Environ. Toxicol. Chem.
机译：本研究调查了2006年从东格陵兰岛斯科斯比桑德（Scoresby Sound）收集的北极熊（Ursus maritimus，n = 19）的八个大脑区域中全氟烷基酸（PFAA）的相对积累。所研究的PFAA是全氟烷基羧酸盐（PFCA，C_6-C_15链长）和磺酸盐（C_4，C_6，C_8和C_10链长）以及包括全氟辛烷磺酰胺在内的选定前体。以湿重计，全脑都发生了全氟辛烷磺酸的血脑屏障运输，尽管与外脑相比，更靠近传入血流的大脑内部区域（脑桥/延髓，丘脑和下丘脑）的PFAA浓度始终较高。区域（小脑，纹状体和额叶，枕叶和颞叶皮层）。对于脑桥/延髓，丘脑和下丘脑，最浓缩的PFAAs是全氟辛烷磺酸盐（PFOS）（湿重为47至58 ng / g）和全氟十三烷酸（湿重为43至49 ng / g）。然而，全脑全氟辛烷磺酸和长链全氟辛烷磺酸（C_10-C_15）与血脂含量显着正相关（p <0.002）。脂质标准化的PFOS和PFCA（C_10-C_15）浓度在各脑区之间无显着差异（p> 0.05）。 PFCA，全氟烷基磺酸盐和全氟辛烷磺酰胺的总负担（平均质量392 g）估计为46μg。本研究表明，PFCA和全氟烷基磺酸盐都可以越过北极熊的血脑屏障，而且湿重浓度是特定于大脑区域的。环境。毒药。化学

著录项

  • 来源
    《Environmental toxicology and chemistry》 |2013年第3期|713-722|共10页
  • 作者

    Alana K. Greaves; Robert J. Letcher; Christian Sonne; Rune Dietz;

  • 作者单位

    Ecotoxicology and Wildlife Health Division, Science and Technology Branch, Environment Canada, and National Wildlife Research Centre and Department of Chemistry, Carleton University, Ottawa, Ontario, Canada;

    Ecotoxicology and Wildlife Health Division, Science and Technology Branch, Environment Canada, and National Wildlife Research Centre and Department of Chemistry, Carleton University, Ottawa, Ontario, Canada;

    Department of Bioscience, Arctic Research Centre, Aarhus University, Roskilde, Denmark;

    Department of Bioscience, Arctic Research Centre, Aarhus University, Roskilde, Denmark;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Perfluorinated Compound; Polyfluoroalkyl Substance; Polar Bear; East Greenland; Brain Region;

    机译：全氟化合物;多氟烷基物质;北极熊;东格陵兰岛;脑区;

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号