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首页> 外文期刊>Environmental toxicology and chemistry >MULTIPLE METALS EXPOSURE AND NEUROTOXIC RISK IN BALD EAGLES(HALIAEETUS LEUCOCEPHALUS) FROM TWO GREAT LAKES STATES
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MULTIPLE METALS EXPOSURE AND NEUROTOXIC RISK IN BALD EAGLES(HALIAEETUS LEUCOCEPHALUS) FROM TWO GREAT LAKES STATES

机译：来自两个大湖州的秃鹰（HALIAEETUS LEUCOCEPHALUS）中的多种金属暴露和神经毒性风险

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摘要

In the present study, the authors determined concentrations of several elements (As, Cd, Co, Cu, Cr, Mn, Pb, Sb, Zn) in the brains and livers of 46 bald eagles (Haliaeetus leucocephalus) from two Great Lakes states, Michigan and Minnesota. To explore whether exposures are of neurological concern, the authors assessed their associations with neurochemical receptors (iV-methyl-D-aspartate [NMDA] and 7-aminobutyric acid A [GABA(A)]) and enzymes (glutamine synthetase [GS] and glutamic acid decarboxylase [GAD]) that play critical roles in vertebrate neurobehavior and reproduction. For most elements, levels in the livers and brains did not differ between region and gender. Hepatic Pb levels averaged 33.1 ppm (dry wt), 30.4% of all carcasses exceeded proposed avian Pb thresholds (>26.4ppm), and in 30.8% of the birds examined evidence of Pb pellets or fragments was found. Significant changes in the activities of GS and GAD were related to brain concentrations of several metals (Pb, Cd, Co, Cu, Zn). No relationships were found among any of the nine elements and NMDA or GABA(A) receptor levels. When combined with the authors' previous study on these same eagles that showed Hg-associated alterations in GS, GAD, and NMDA receptor levels, the present research suggests that bald eagles are exposed to various elements, especially Pb and Hg, that are capable of causing changes in GABAergic and glutamatergic neurotransmission. The functional significance of these neurochemical changes warrants attention. Environ. Toxicol. Chem.
机译：在本研究中，作者确定了两个大湖州46头秃鹰（Haliaeetus leucocephalus）的大脑和肝脏中几种元素（As，Cd，Co，Cu，Cu，Cr，Mn，Pb，Sb，Zn）的浓度，密歇根州和明尼苏达州。为了探讨暴露是否与神经系统有关，作者评估了它们与神经化学受体（iV-甲基-D-天冬氨酸[NMDA]和7-氨基丁酸A [GABA（A）]）和酶（谷氨酰胺合成酶[GS]和谷氨酸脱羧酶（GAD））在脊椎动物的神经行为和繁殖中起关键作用。对于大多数元素，区域和性别之间肝脏和大脑中的水平没有差异。肝铅水平平均为33.1 ppm（干重），所有car体中30.4％超过了建议的禽Pb阈值（> 26.4ppm），并且在30.8％的鸟类中发现了Pb颗粒或碎片的证据。 GS和GAD活性的显着变化与几种金属（铅，镉，钴，铜，锌）的大脑浓度有关。九个元素中的任何一个与NMDA或GABA（A）受体水平之间均未发现相关性。当与作者先前对这些老鹰的研究相结合时，这些老鹰表明GS，GAD和NMDA受体水平与汞有关，因此本研究表明，白头鹰会暴露于各种元素，尤其是Pb和Hg。导致GABA能和谷氨酸能神经传递发生变化。这些神经化学变化的功能意义值得关注。环境。毒药。化学

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  • 来源
    《Environmental toxicology and chemistry》 |2012年第3期|p.623-631|共9页
  • 作者

    Dong-Ha Nam; Jennifer Rutkiewicz; Niladri Basu;

  • 作者单位

    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA;

    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA;

    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    neurochemical biomarkers; neurotoxicology; wildlife toxicology; heavy metals; brain; lead;

    机译：神经化学生物标志物;神经毒理学野生生物毒理学;重金属;脑;铅;

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