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首页> 外文期刊>Environmental toxicology and chemistry >STRUCTURAL AND FUNCTIONAL CHANGES IN GILL MITOCHONDRIAL MEMBRANES FROM THE MEDITERRANEAN MUSSEL MYTILUS GALLOPROVINCIALIS EXPOSED TO TRI-N-BUTYLTIN
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STRUCTURAL AND FUNCTIONAL CHANGES IN GILL MITOCHONDRIAL MEMBRANES FROM THE MEDITERRANEAN MUSSEL MYTILUS GALLOPROVINCIALIS EXPOSED TO TRI-N-BUTYLTIN

机译：暴露于三正丁基锡的地中海芒MY变种的G线粒体膜的结构和功能变化

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摘要

The use of tributyltin (TBT) as a biocide in antifouling paints leads to a ruinous input of this contaminant in the aquatic environment. Human exposure to TBT mainly occurs through ingestion of contaminated seafood such as filter-feeding mollusks. Tributyltin is known to act as a membrane-active toxicant on several targets, but especially on the mitochondria, and by several mechanisms. The effects of tributyltin on fatty acid composition, on Mg-adenosine triphosphatase (ATPase) activities, and on the membrane physical state were investigated in gill mitochondrial membranes from cultivated mussels Mytilus galloprovincialis exposed to 0.5 μg/L and 1.0μg/L TBT and unexposed for 120 h. The higher TBT exposure dose induced a decrease in the total and n-3 polyunsaturated fatty acids (PUFAs), especially 22:6 n-3, and an activation of the oligomycin-sensitive Mg-ATPase. Both TBT concentrations decreased mitochondrial membrane polarity detected by Laurdan steady-state fluorescence spectroscopy. These findings may help cast light on the multiple modes of action of this toxicant.
机译：在防污漆中使用三丁基锡（TBT）作为杀生物剂会导致这种污染物在水生环境中的破坏性输入。人体接触三丁基锡化合物的主要途径是摄入诸如滤食性软体动物等污染的海鲜。已知三丁基锡在几种靶标上，尤其是在线粒体上，通过多种机理起膜活性毒物的作用。在暴露于0.5μg/ L和1.0μg/ L TBT且未暴露的人工养殖贻贝的til线粒体膜中，研究了三丁基锡对脂肪酸组成，Mg-腺苷三磷酸酶（ATPase）活性以及膜物理状态的影响。持续120小时。较高的TBT暴露剂量引起总和n-3多不饱和脂肪酸（PUFA）的减少，尤其是22：6 n-3的减少，以及对寡霉素敏感的Mg-ATPase的激活。两种TBT浓度均降低了通过Laurdan稳态荧光光谱法检测到的线粒体膜极性。这些发现可能有助于阐明这种有毒物质的多种作用方式。

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  • 来源
    《Environmental toxicology and chemistry》 |2012年第4期|p.877-884|共8页
  • 作者

    Rosamaria Fiorini; Alessandra Pagliarani; Salvatore Nesci; Maurizio Pirini; Elisabetta Tucci; Vittoria Ventrella;

  • 作者单位

    Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy;

    Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia (Bologna), Italy;

    Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia (Bologna), Italy;

    Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia (Bologna), Italy;

    Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy;

    Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia (Bologna), Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    tributyltin; mussel gills; mitochondrial Mg-ATPase; laurdan fluorescence; fatty acids;

    机译：三丁基锡贻贝;线粒体Mg-ATP酶;劳丹荧光;脂肪酸;

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