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首页> 外文期刊>Environmental toxicology and chemistry >ACUTE AND SUBACUTE ORAL TOXICITY OF POLYCHLORINATED DIPHENYL SULFIDES IN MICE: DETERMINING LD50 AND ASSESSING THE STATUS OF HEPATIC OXIDATIVE STRESS
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ACUTE AND SUBACUTE ORAL TOXICITY OF POLYCHLORINATED DIPHENYL SULFIDES IN MICE: DETERMINING LD50 AND ASSESSING THE STATUS OF HEPATIC OXIDATIVE STRESS

机译：氯化多酚对小鼠的急性和急性口腔毒性：测定LD50和评估肝氧化应激状态

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摘要

Polychlorinated diphenyl sulfides (PCDPSs), a series of dioxin-like compounds, have been detected in various environmental samples. However, information on the toxicity of these compounds is limited. In the present study, the toxic effects of PCDPSs were assessed after acute and subacute exposure in mice. Relationships between acute toxicity, number, and position of substituted Cl atoms were assessed. In the acute study, 11 types of PCDPSs were administered to female Kunming mice by gavage, and median lethal doses (LD50s) were determined by the Karber method. Results indicated that the LD50s of lower substituted PCDPSs were smaller than higher substituted PCDPSs. Substituted positions also influenced the LD50 of PCDPSs. Terminal necropsy showed increased relative liver weights and decreased relative kidney weights. Histological examination of livers demonstrated swollen cells, inflammation, vacuolization, and necrosis. In the 28-d subacute exposure tests, 11 types of PCDPSs were dissolved in corn oil and administered to mice at doses of 1,10, and 100 mg/kg. Superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels in mouse liver were determined after the exposure period. Results suggested that lower substituted PCDPSs decreased SOD activity in the high-dose groups compared with controls, and MDA level in the 100-mg/kg dose group was significantly increased. In addition, acute toxicity of PCDPSs partly corresponded to the hepatic oxidative damage observed.
机译：多氯联苯硫化物（PCDPS）是一系列二恶英类化合物，已在各种环境样品中检测到。但是，有关这些化合物毒性的信息有限。在本研究中，在小鼠急性和亚急性暴露后评估了PCDPS的毒性作用。评估了急性毒性，数量和取代Cl原子的位置之间的关系。在急性研究中，通过强饲法给雌性昆明小鼠施用了11种PCDPS，并通过Karber方法确定了中值致死剂量（LD50）。结果表明，较低取代的PCDPS的LD50小于较高取代的PCDPS。替代职位也影响了PCDPS的LD50。晚期尸检显示相对肝脏重量增加，相对肾脏重量减少。肝脏的组织学检查显示细胞肿胀，发炎，空泡形成和坏死。在28天的亚急性暴露测试中，将11种PCDPS溶解在玉米油中，并以1,10和100 mg / kg的剂量施用于小鼠。暴露期后测定小鼠肝脏中的超氧化物歧化酶（SOD）活性和丙二醛（MDA）水平。结果表明，与对照组相比，低剂量的PCDPS降低了高剂量组的SOD活性，并且100 mg / kg剂量组的MDA水平显着增加。此外，PCDPS的急性毒性部分与观察到的肝氧化损伤相对应。

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  • 来源
    《Environmental toxicology and chemistry》 |2012年第7期|p.1485-1493|共9页
  • 作者

    XUESHENG ZHANG; Fu LIU; BINYUAN CHEN; YING LI; ZUNYAO WANG;

  • 作者单位

    State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing, P.R. China;

    State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing, P.R. China;

    Department of Environmental and Safety Engineering, Changzhou University, Changzhou, P.R. China;

    State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing, P.R. China;

    State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing, P.R. China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    polychlorinated diphenyl sulfides; median lethal dose; toxicity; histological analysis; oxidative stress;

    机译：多氯二苯硫醚;中位致死剂量;毒性;组织学分析;氧化应激;

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