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首页> 外文期刊>Environmental toxicology and chemistry >HEXABROMOCYCLODODECANE IN CONSUMER FISH FROM SOUTH CHINA:IMPLICATIONS FOR HUMAN EXPOSURE VIA DIETARY INTAKE
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HEXABROMOCYCLODODECANE IN CONSUMER FISH FROM SOUTH CHINA:IMPLICATIONS FOR HUMAN EXPOSURE VIA DIETARY INTAKE

机译：中国南方食用鱼中的六溴环十二烷：通过饮食摄入对人体的影响

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摘要

Levels of hexabromocyclododecane (HBCD) were determined in 12 consumer fish species from South China. The concentrations of the sum of HBCD diastereoisomers (2HBCD) ranged from nondetectable to 194 pg/g wet weight, with a detectable frequency of 70%. This was at the low end of the concentration range globally observed. Carnivorous fish species contained higher HBCD concentrations than herbivorous and detritivorous ones, suggesting the potential for biomagnification of HBCDs via the trophic chain. Moreover, XHBCD concentrations were higher in both freshwater and seawater farmed fish than in wild marine fish, indicating that human activities were probably an important input source of HBCD in aquaculture. Among the three diastereoisomers, α-HBCD dominated in most samples, with a mean relative abundance of 70%. In agreement with previous studies, a difference in the diastereomer patterns was observed from commercial products and several environmental media to biota samples. For farm-raised snubnose pompano, the concentrations of ∑HBCD were moderately linearly correlated with lipid contents but were not significantly correlated with fish body lengths and weights. In the worst-case exposure, the mean estimated daily intake of XHBCD via fish consumption for residents of South China ranged from 13 to 16 pg/kg body weight/d for various age groups, much lower than its lowest observed adverse effect level derived from a two-generation reproductive toxicity study on rats.
机译：确定了来自中国南方的12种食用鱼类的六溴环十二烷（HBCD）水平。六溴环十二烷非对映异构体总量（2HBCD）的浓度范围为无法检测到湿重194 pg / g，可检测频率为70％。这是全球观察到的浓度范围的低端。食肉鱼类的六溴环十二烷浓度高于草食性和有害性六溴环十二烷，这表明通过营养链将六溴环十二烷生物放大。此外，淡水和海水养殖鱼类中的XHBCD浓度均高于野生海鱼，这表明人类活动可能是水产养殖中HBCD的重要输入来源。在这三种非对映异构体中，大多数样品中α-六溴环十二烷占主导地位，平均相对丰度为70％。与先前的研究一致，从商业产品和几种环境介质到生物群样品，观察到非对映体模式的差异。对于农场饲养的金丝雀mp，∑HBCD的浓度与脂质含量呈中等线性相关，但与鱼的体长和体重无显着相关。在最坏的情况下，不同年龄段的华南居民平均每天通过食用鱼类摄入的六溴环十二烷的日摄入量在13至16皮克/千克体重/天之间，远低于其观察到的最低最低不良反应水平。对大鼠的两代生殖毒性研究。

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  • 来源
    《Environmental toxicology and chemistry》 |2012年第7期|p.1424-1430|共7页
  • 作者

    Xiang-Zhou MENG; Nan Xiang; Yan-Ping Duan; Ling Chen; Eddy Y. Zeng;

  • 作者单位

    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai, China;

    State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai, China;

    State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai, China;

    State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai, China;

    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    hexabromocyclododecane; diastereomer pattern; human exposure; fish consumption; south china;

    机译：六溴环十二烷非对映体人体暴露;鱼类消费;中国南方;

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