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首页> 外文期刊>Environmental toxicology and chemistry >PARTIAL LIFE-CYCLE AND ACUTE TOXICITY OF PERFLUOROALKYL ACIDS TO FRESHWATER MUSSELS
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PARTIAL LIFE-CYCLE AND ACUTE TOXICITY OF PERFLUOROALKYL ACIDS TO FRESHWATER MUSSELS

机译:全氟烷基酸对淡水牡蛎的部分生命周期和急性毒性

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摘要

Freshwater mussels are among the most sensitive aquatic organisms to many contaminants and have complex life-cycles that include several distinct life stages with unique contaminant exposure pathways. Standard acute (24-96 h) and chronic (28 d) toxicity tests with free larva (glochidia) and juvenile mussels are effective at generating data on contaminant effects at two discrete life stages but do not incorporate effects on brooded glochidia. We developed a novel partial life-cycle assay that incorporates exposures to brooding adult female mussels and used this method in combination with acute toxicity tests to assess adverse effects of perfluoroctanesulfonic acid (PFOS) and perfluoroctanoic acid (PFOA) on freshwater mussels. Fatmucket (Lampsilis siliquoidea) were exposed to PFOS at two life stages: brooding glochidia (in marsupia) for 36 d and free glochidia in water for 24 h. In standard acute tests with glochidia (24-48 h exposures) and juveniles (48-96 h exposures) of fatmucket and black sandshell (Ligumia recta), glochidia were 8 to 25 times more sensitive than juveniles. Perfluoroctanesulfonic acid significantly reduced the duration of glochidia viability and reduced probability of metamorphosis at concentrations 3,000 times lower than the most sensitive acute endpoint (24-h EC50). The partial life-cycle test is adaptable to a variety of endpoints and research objectives and is useful for identifying adverse effects at contaminant concentrations below those required for an acute lethal response.
机译:淡水贻贝是对许多污染物最敏感的水生生物之一,其生命周期复杂,包括具有独特的污染物暴露途径的几个不同的生命阶段。用游离幼虫(贻贝)和幼贻贝进行标准的急性(24-96 h)和慢性(28 d)毒性试验可有效地在两个不连续的生命阶段生成有关污染物影响的数据,但不包括对育成的球藻的影响。我们开发了一种新颖的部分生命周期测定方法,该方法将暴露于成年成年雌性贻贝的暴露纳入其中,并将此方法与急性毒性试验结合使用,以评估全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)对淡水贻贝的不利影响。 Fatmucket(Lampsilis siliquoidea)在两个生命阶段都暴露于全氟辛烷磺酸:孵化glochidia(在有袋动物中)36 d和水中游离glochidia 24 h。在标准的急性测试中,胖子和黑沙壳(Ligumia recta)的小球虫(24-48 h暴露)和少年(48-96 h暴露),比青少年的敏感度高8至25倍。全氟辛烷磺酸的浓度比最敏感的急性终点(24-h EC50)低3,000倍,从而显着降低了球虫生存力的持续时间并降低了变态的可能性。部分生命周期测试适用于各种终点和研究目标,可用于识别污染物浓度低于急性致死反应所需浓度的不利影响。

著录项

  • 来源
    《Environmental toxicology and chemistry》 |2012年第7期|p.1611-1620|共10页
  • 作者单位

    University of Georgia, Interdisciplinary Toxicology Program, Warnell School of Forestry and Natural Resources, Athens, Georgia, USA;

    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, USA;

    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, USA;

    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, USA;

    U.S. Environmental Protection Agency, Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory,Research Triangle Park, North Carolina, USA;

    Department of Biology, Missouri State University, Springfield, Missouri, USA;

    University of Georgia, Interdisciplinary Toxicology Program, Warnell School of Forestry and Natural Resources, Athens, Georgia, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    perfluoroalkyl acids; perfluorinated compounds; akaike's information criteria; unionidae;

    机译:全氟烷基酸全氟化合物;赤池的信息标准;ida科;

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