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首页> 外文期刊>Environmental toxicology and chemistry >ISOMER-SPECIFIC ACCUMULATION OF PERFLUOROOCTANE SULFONATE IN THE LIVER OF CHICKEN EMBRYOS EXPOSED IN OVO TO A TECHNICAL MIXTURE
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ISOMER-SPECIFIC ACCUMULATION OF PERFLUOROOCTANE SULFONATE IN THE LIVER OF CHICKEN EMBRYOS EXPOSED IN OVO TO A TECHNICAL MIXTURE

机译：卵母乳暴露于技术混合物中时，全氟辛烷磺酸的异构体积累

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摘要

Prior to its recent phaseout, perfluorooctane sulfonate (PFOS) was produced by electrochemical fluorination processes, which yielded technical mixtures composed of linear isomer (～65-79%) and several branched isomers (～21-35%). Because PFOS can biomagnify in wildlife, birds that occupy higher trophic levels are at increased risk of exposure. We hypothesized that the pharmacokinetic properties of PFOS are isomer-specific in developing chicken (Gallus gallus domesticus) embryos exposed to technical grade PFOS (T-PFOS). In the present study, T-PFOS was composed of 62.7% linear isomer (L-PFOS), and 37.3% branched isomer, including six mono(trifluoromethyl)-branched isomers and four bis(trifluoromethyl)-branched isomers. Concentrations of 0.1,5, or 100 μg/g of T-PFOS were injected into the air cell of chicken eggs prior to incubation. After pipping, compared with T-PFOS, the PFOS isomer profile in embryonic liver tissue for the 0.1 μg/g dose group showed 21% enrichment in the proportion of L-PFOS with a corresponding decrease in the proportion of branched isomers. Not all branched isomers were discriminated against at equal rates. The proportion of two mono(trifluoromethyl)-branched isomers and three bis(trifluoromethyl)-branched isomers decreased to a greater degree than other branched isomers. In contrast, the mono-branched isomer, P6MHpS, was overrepresented in the low-dose group. In the higher dose groups, L-PFOS was still enriched but only by approximately 10%, which indicated a dose-dependent change in isomer composition relative to T-PFOS. These results show that accumulation of PFOS in chicken embryo livers is dependent on the presence and position of branches on the alkyl backbone. This supports the hypothesis that the pharmacokinetics of PFOS are isomer-specific in biota, and may help explain why wildlife PFOS burdens are dominated by L-PFOS relative to T-PFOS mixtures.
机译：在最近淘汰之前，全氟辛烷磺酸盐（PFOS）是通过电化学氟化工艺生产的，产生了由线性异构体（〜65-79％）和几种支链异构体（〜21-35％）组成的技术混合物。由于全氟辛烷磺酸可以在野生生物中生物放大，因此，具有较高营养水平的鸟类面临的暴露风险更高。我们假设在暴露于工业级PFOS（T-PFOS）的发育中的鸡（Gallus gallus domesticus）胚胎中，PFOS的药代动力学特性是异构体特异性的。在本研究中，T-PFOS由62.7％的线性异构体（L-PFOS）和37.3％的支链异构体组成，其中包括6个单（三氟甲基）支链异构体和4个双（三氟甲基）支链异构体。在孵育之前，将浓度为0.1、5或100μg/ g的T-PFOS注入鸡蛋的气室中。浸泡后，与T-PFOS相比，0.1μg/ g剂量组的胚胎肝组织中的PFOS异构体谱显示L-PFOS的比例富集了21％，支链异构体的比例相应降低。并非所有的分支异构体都以相同的比率被区别对待。与其他支化异构体相比，两种单（三氟甲基）支化异构体和三种双（三氟甲基）支化异构体的比例降低的程度更大。相反，低剂量组中的单支链异构体P6MHpS过多。在较高剂量组中，L-PFOS仍富集，但仅富集约10％，这表明相对于T-PFOS，异构体组成呈剂量依赖性变化。这些结果表明，全氟辛烷磺酸在鸡胚肝脏中的积累取决于烷基主链上分支的存在和位置。这支持了全生物体内全氟辛烷磺酸的药代动力学是异构体特异性的假设，并且可能有助于解释为什么野生生物全氟辛烷磺酸负担相对于T-PFOS混合物而言，L-PFOS占主导地位。

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  • 来源
    《Environmental toxicology and chemistry》 |2011年第1期|p.226-231|共6页
  • 作者

    Jason M. OBrien; Sean W. Kennedy; Shaogang Chu; Robert J. Letcher;

  • 作者单位

    Centre for Advanced Research in Environmental Genomics, University of Ottawa, 20 Marie Curie Street, Ottawa, Ontario KIN 6N5, Canada,Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Ontario, Canada;

    Centre for Advanced Research in Environmental Genomics, University of Ottawa, 20 Marie Curie Street, Ottawa, Ontario KIN 6N5, Canada;

    Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Ontario, Canada;

    Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Ontario, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    chicken egg injection; embryonic livers; liver patterns; perfluorooctane sulfonate; linear/branched isomers;

    机译：鸡蛋注射胚胎肝脏;肝脏模式全氟辛烷磺酸;线性/支链异构体;

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