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首页> 外文期刊>Environmental toxicology and chemistry >MEASURING THE TOXICITY OF ALKYL-PHENANTHRENES TO EARLY LIFE STAGES OF MEDAKA (ORYZIAS LATIPES) USING PARTITION-CONTROLLED DELIVERY
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MEASURING THE TOXICITY OF ALKYL-PHENANTHRENES TO EARLY LIFE STAGES OF MEDAKA (ORYZIAS LATIPES) USING PARTITION-CONTROLLED DELIVERY

机译：用分区控制的传递量测定烷基菲对幼年幼年期的毒性。

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Alkyl-phenanthrenes are a class of compounds present in crude oil and toxic to developing fish. Most research on alkyl-phenanthrenes has focused on retene (7-isopropyl-1-methyl-phenanthrene), but little is known about the chronic toxicity of related congeners to the early life stages of fish. This project is the first to describe the chronic toxicity of a series of alkyl-phenanthrenes to the embryos of Japanese medaka (Oryzias latipes) using the partition-controlled delivery (PCD) method of exposure and is the first to establish a relationship between toxicity of alkyl-phenanthrenes and log P. With PCD, test concentrations were maintained by equilibrium partitioning of test chemicals from polydimethylsiloxane (PDMS) films containing various concentrations of Cl to C4 phenanthrenes. Log film:solution partition constants (log K_(fs)) and aqueous solubility limits were determined for each alkyl-phenan-threne. The prevalence of abnormalities in fish embryos increased in an exposure-dependent manner, with median effective concentration (EC50) values lower than experimental solubility limits of the compounds, and typical of environmental concentrations. Alkyl-phenanthrenes were more toxic to medaka embryos than unsubstituted phenanthrene, with effects resembling those of dioxin and indicating a specific receptor-based mechanism of toxicity. These results extend conclusions for the Exxon Valdez oil spill, suggest a specific mechanism of toxicity for alkyl-phenanthrenes, and provide a model for assessing the risks of mixture toxicity.
机译：烷基菲是存在于原油中的一类化合物，对发育中的鱼类有毒。关于烷基菲的大多数研究都集中在视黄烯（7-异丙基-1-甲基菲）上，但对相关同源物对鱼类早期生命的慢性毒性知之甚少。该项目是第一个使用分区控制递送（PCD）暴露方法描述一系列烷基菲对日本（Oryzias latipes）胚胎的慢性毒性的方法，并且是第一个建立氯霉素毒性之间关系的方法。烷基菲和对数P。使用PCD时，通过将测试化学品与含有各种浓度的C1至C4菲的聚二甲基硅氧烷（PDMS）膜进行平衡分配，可以保持测试浓度。对每个烷基-菲蒽确定对数膜：溶液分配常数（log K_（fs））和水溶解度极限。鱼胚中异常的患病率以依赖于暴露的方式增加，中值有效浓度（EC50）值低于化合物的实验溶解度限值，并且是典型的环境浓度。烷基菲对青aka胚的毒性比未取代的菲更具毒性，其作用类似于二恶英，表明特定的基于受体的毒性机制。这些结果扩展了对埃克森·瓦尔迪兹石油泄漏的结论，提出了烷基菲的特定毒性机理，并提供了评估混合物毒性风险的模型。

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