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首页> 外文期刊>Journal of applied toxicology >Effects of triclosan on Japanese medaka ( Oryzias latipes Oryzias latipes Oryzias latipes ) during embryo development, early life stage and reproduction
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Effects of triclosan on Japanese medaka ( Oryzias latipes Oryzias latipes Oryzias latipes ) during embryo development, early life stage and reproduction

机译：Triclosan对胚胎发育期间日本Medaka（Oryzias Lakipes Oryzias Lakipes Oryzias Lavipes）的影响，早起阶段和繁殖

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Abstract Triclosan has been shown to have endocrinedisrupting effects in aquatic organisms. In 2016, the US Food and Drug Administration banned the use of triclosan in consumer soaps. Before the ban, triclosan was reported at low concentrations in the aquatic environment, although the effect of triclosan on reproduction in teleost fish species is yet to be clarified. Here we investigated the effects of triclosan on embryo development and reproduction, and during the early life stage, in Japanese medaka (Oryzias latipes ) by using Organisation for Economic Cooperation and Development tests 229, 212 and 210, with minor modifications. In adult medaka, exposure to 345.7牸g l1 suppressed fecundity and increased mortality but had no effect on fertility. Exposure to 174.1 or 345.7牸g l1 increased liver vitellogenin concentration in females but decreased liver vitellogenin concentration in males. With triclosan exposure, mortality was increased dose dependently during the embryonic and early larval stages, and a particularly steep increase in mortality was observed soon after hatching. The lowest observed effect concentrations of triclosan in Japanese medaka obtained in the present study (mortality [embryonic and larval stages, 276.3牸g l1 ; early life stage, 134.4牸g l1 ; adult stage, 174.1牸g l1 ], growth [134.4牸g l1 ], vitellogenin [174.1牸g l1 ], fecundity [345.7牸g l1 ] and fertility [345.7牸g l1 ]) were at least 55 times (compared with the USA) and up to 13 400 times (compared with Germany) greater than the detected triclosan levels in the aquatic environment. These results suggest that triclosan may not be affecting fish populations in the aquatic environment.
机译：摘要三胞苷已被证明在水生生物中具有内分泌缺陷作用。 2016年，美国食品和药物管理局禁止在消费者肥皂中使用三氯烷。在禁令之前，在水生环境中以低浓度报告三胞石，尽管Triclosan对Textost鱼类中的繁殖的影响尚未澄清。在这里，我们调查了Triclosan对日本Medaka（Oryzias Lipees）的胚胎发育和繁殖的影响，在日本Medaka（Oryzias Lipipes）中，通过进行经济合作和开发试验229,212和210，进行了微小的修改。在成人麦卡卡中，暴露于345.7‰GL1抑制繁殖力和增加的死亡率，但对生育率没有影响。暴露于174.1或345.7℃g l1增加了女性的肝脏Vitellogen浓度，但在雄性中降低了肝脏vallogenin浓度。通过三胞气孔暴露，在胚胎和早期幼虫阶段期间，死亡率依赖性增加剂量，并且在孵化后不久会观察到死亡率的特别陡峭的增加。在本研究中获得的日本MEDAKA中的TRICLOSAN的最低观察到浓度（死亡率[胚胎和幼虫阶段，276.3‰;早期寿命期，134.4‰GL1;成人阶段，174.1‰G L1]，增长[134.4 vl1]，vitellogenin [174.1〜g l1]，繁殖力[345.7〜g l1]和生育率[＆ 345.7牸g l1]）至少为55倍（与美国相比），最高可达13次（与德国）大于水生环境中检测到的三胞沙山水平。这些结果表明Triclosan可能不会影响水生环境中的鱼群。

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