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首页> 外文期刊>Environmental toxicology and chemistry >TISSUE-SPECIFIC TOXICOLOGICAL EFFECTS OF CADMIUM IN GREEN MUSSELS (PERNA VIRIDIS): NUCLEAR MAGNETIC RESONANCE-BASED METABOLOMICS STUDY
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TISSUE-SPECIFIC TOXICOLOGICAL EFFECTS OF CADMIUM IN GREEN MUSSELS (PERNA VIRIDIS): NUCLEAR MAGNETIC RESONANCE-BASED METABOLOMICS STUDY

机译：镉在绿色贻贝中的组织特异性毒理学效应：基于核磁共振的代谢组学研究

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摘要

Toxicity tests for metals have traditionally focused on selected biomarkers to characterize the biological stress induced by metals in marine organisms. Here nuclear magnetic resonance (NMR)-based metabolomics, a system biology tool, was applied to the marine green mussel, Perna viridis, to investigate the toxicological effects of Cd in both digestive gland and adductor muscle tissues. After Cd exposure for either two or four weeks, there was no significant metabolic change in the mussels exposed to Cd at 2 μg/L. At 20 μg/L, there were major metabolite changes related to amino acids, osmolytes, and energy metabolites. Digestive gland tissue was more sensitive to Cd than adductor muscle tissue. The adductor muscle tissue showed elevated levels of glutamine, glutamate, and lactate, and reduced levels of branched chain amino acids, aspartate, phenylalanine, and tyrosine. Overall, four weeks of Cd exposure produced neurotoxicity and metabolic disturbances and disturbed osmoregulation. These results suggest that the adductor muscle tissue of mussels may be a suitable supplemental biomarker for exposure to toxicants. In addition, the results demonstrate that' H-NMR-based metabolomic analysis can provide a systematic view of the toxicological effects of metals on mussels, suggesting that it might be employed to investigate the toxicological effects of other marine pollutants.
机译：传统上，金属的毒性测试集中于选定的生物标记物，以表征金属在海洋生物中引起的生物胁迫。在这里，基于核磁共振（NMR）的代谢组学（一种系统生物学工具）被应用到海洋绿色贻贝Perna viridis中，以研究Cd在消化腺和内收肌组织中的毒理作用。镉暴露两到四周后，贻贝暴露于2μg/ L的贻贝没有明显的代谢变化。在20μg/ L时，主要的代谢物变化与氨基酸，渗透压和能量代谢物有关。消化腺组织对Cd的敏感性比内收肌组织高。内收肌组织显示谷氨酰胺，谷氨酸和乳酸水平升高，而支链氨基酸，天冬氨酸，苯丙氨酸和酪氨酸水平降低。总体而言，镉暴露四周会产生神经毒性和代谢紊乱以及渗透调节紊乱。这些结果表明，贻贝的内收肌组织可能是暴露于有毒物质的合适补充生物标志物。此外，结果表明，基于1 H-NMR的代谢组学分析可以提供金属对贻贝的毒理学作用的系统视图，表明它可以用于研究其他海洋污染物的毒理学作用。

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  • 来源
    《Environmental toxicology and chemistry》 |2011年第4期|p.806-812|共7页
  • 作者

    Huifeng Wu; Wen-Xiong Wang;

  • 作者单位

    State Key Laboratory in Marine Pollution, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong;

    State Key Laboratory in Marine Pollution, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cadmium; toxicity; mussels; nuclear magnetic resonance; metabolomics;

    机译：镉;毒性;青口贝;核磁共振代谢组学;

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