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首页> 外文期刊>Environmental toxicology and chemistry >EFFECTS OF P-ENDOSULFAN ON THE GROWTH AND REPRODUCTION OF ZEBRAFISH (DANIO RERIO)
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EFFECTS OF P-ENDOSULFAN ON THE GROWTH AND REPRODUCTION OF ZEBRAFISH (DANIO RERIO)

机译：对硫丹对斑马鱼（DANIO RERIO）的生长和繁殖的影响

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摘要

Because of persistent organic pollution in aquatic environments, the widely used organochlorine pesticide endosulfan, which is a potential endocrine disruptor, is expected to pose a significant risk to aquatic organisms. In the present study, we explored the potential endocrine-disrupting risk of β-endosulfan by investigating its effect on the growth, reproduction, plasma vitellogenin, and organ histology of adult zebrafish. We found that, although β-endosulfan did not significantly affect the growth of zebrafish, it greatly decreased the hatching rate, even at a concentration as low as 10ng/L. Interestingly, the decrease of the hatching rate was highly correlated with pathological alterations of the testes. Additionally, the values of the gonadosomatic index were significantly reduced in female zebrafish treated with 200ng/L β-endosulfan, which was also closely associated with ovarian histological changes. More importantly, a significant increase in the level of vitellogenin was observed in all male fish treated with p-endosulfan. Based on these findings, we conclude that P-endosulfan severely affects the reproductive function of zebrafish and the synthesis of vitellogenin in the liver, and thus, 3-endosulfan has a serious endocrine disruption function in zebrafish.
机译：由于在水生环境中持续的有机污染，被广泛使用的有机氯农药硫丹是潜在的内分泌干扰物，预计会对水生生物构成重大风险。在本研究中，我们通过研究β-硫丹对成年斑马鱼的生长，繁殖，血浆卵黄蛋白原和器官组织学的影响，探索了破坏β-硫丹的潜在内分泌风险。我们发现，尽管β-硫丹对斑马鱼的生长没有显着影响，但即使浓度低至10ng / L，它也大大降低了孵化率。有趣的是，孵化率的降低与睾丸的病理改变高度相关。此外，在用200ng / Lβ-硫丹处理的雌性斑马鱼中，性腺体指数值显着降低，这也与卵巢组织学变化密切相关。更重要的是，在用对硫丹处理的所有雄鱼中观察到卵黄蛋白原水平显着增加。基于这些发现，我们得出结论，P-硫丹严重影响斑马鱼的繁殖功能和肝脏中卵黄蛋白原的合成，因此3-硫丹在斑马鱼中具有严重的内分泌破坏功能。

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  • 来源
    《Environmental toxicology and chemistry》 |2011年第11期|p.2525-2531|共7页
  • 作者

    Zhihua Han; Shaojun Jiao; Deyang Kong; Zhengjun Shan; Xiaowei Zhang;

  • 作者单位

    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China,Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing, China,Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Ministry of Environmental Protection of China, Nanjing, China;

    Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing, China,Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Ministry of Environmental Protection of China, Nanjing, China;

    Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing, China,Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Ministry of Environmental Protection of China, Nanjing, China;

    Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing, China,Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Ministry of Environmental Protection of China, Nanjing, China;

    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    β-endosulfan; zebrafish; endocrine disruption; vitellogenin;

    机译：β-硫丹;斑马鱼内分泌干​​扰卵黄蛋白原;

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