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首页> 外文期刊>Environmental toxicology and chemistry >STAGE-DEPENDENT SUSCEPTIBILITY TO COPPER IN RHINELLA ARENARUM EMBRYOS AND LARVAE
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STAGE-DEPENDENT SUSCEPTIBILITY TO COPPER IN RHINELLA ARENARUM EMBRYOS AND LARVAE

机译：HI毛和幼虫对铜的阶段依赖性

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摘要

Copper toxicity in different embryonic and larval stages of the common South American toad Rhinella arenarum was evaluated by means of continuous and 24-h pulse treatments in 12 different developmental stages. Lethal concentrations (LC) of 10, 50, and 90% of continuous treatment with Cu from early blastula (S.4), complete operculum (S.25), and hind limb bud (S.28) stages were plotted from 24 to 168 h, resulting from S.4 in a 24-h LC50 of 137 μg Cu~(2+)/L and a 168-h LC50 of 19.5 μg Cu~(2+)/L. This result was in agreement with pulse treatments that showed a high resistance to Cu at blastula and gastrula stages, whereas the organogenic period, between muscular response (S.18) and open mouth (S.21), was very susceptible to this metal. Continuous treatments from S.25 showed no significant differences along exposure time (168-h LC50 = 51 μg Cu~(2+)/L), but in the case of S.28 toxicity increased slightly from a 24-h LC50 of 138.6 μg Cu~(2+)/L to a 168-h LC50 of 104 μg Cu~(2+)/L, pointing out that, although the larval period was significantly more resistant to Cu, there was also a remarkable stage-dependent susceptibility to this metal. Copper teratogenic potential was approximately two, and main adverse effects were reduced body size, axial flexure, microcephaly, acephaly, mouth malformations, agenesis of or underdeveloped gills, agenesis of or underdeveloped tail, and hydropsy. The results are discussed considering Cu toxicity mechanisms, an evolutionary perspective, and environmental protection.
机译：通过在12个不同的发育阶段进行连续和24小时脉冲处理，评估了南美蟾蜍常见的蟾蜍球果在不同胚胎和幼虫阶段的铜毒性。绘制了从早期囊胚（S.4），完全盖（S.25）和后肢芽（S.28）阶段铜持续治疗的致死浓度（LC）的10％，50％和90％的阶段，从24绘制为S.4得出的168小时LC50为137μgCu〜（2 +）/ L，168-h LC50为19.5μgCu〜（2 +）/ L。该结果与脉冲处理相一致，脉冲处理在囊泡期和胃胚期对铜具有很高的抵抗力，而肌肉反应（S.18）和张开嘴（S.21）之间的器官形成时期对这种金属非常敏感。从S.25开始的连续处理未显示出沿暴露时间的显着差异（168-h LC50 = 51μgCu〜（2 +）/ L），但在S.28情况下，毒性从24.h LC50略有增加，为138.6 μgCu〜（2 +）/ L至168-h LC50为104μgCu〜（2 +）/ L，指出尽管幼体期对Cu的抗性明显增强，但也存在明显的阶段依赖性对这种金属的敏感性。铜的致畸潜力约为2，主要的不良反应包括体型缩小，轴向弯曲，小头畸形，无头畸形，口腔畸形，g发育不全或发育不全，尾部发育不全或发育不全以及活检。讨论结果时考虑了铜的毒性机理，进化观点和环境保护。

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  • 来源
    《Environmental toxicology and chemistry》 |2011年第12期|p.2771-2777|共7页
  • 作者

    Carolina M. Aronzon; Maria Teresa Sandoval; Jorge Herkovits; Cristina S. PerezColl;

  • 作者单位

    Programa de Seguridad Quimica, Instituto de Ciencias Ambientales y Salud (ICAS), Fundacion PROSAMA, Buenos Aires, Argentina;

    Laboratorio de Herpetologia, Facultad de Ciencias Exactas y Naturales y Agrimensura, Universidad Nacional del Nordeste, Corrientes, Argentina;

    Programa de Seguridad Quimica, Instituto de Ciencias Ambientales y Salud (ICAS), Fundacion PROSAMA, Buenos Aires, Argentina;

    Instituto de Investigation e Ingenieria Ambiental, Universidad Nacional de San Martin, Buenos Aires, Argentina;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    amphibian embryos; copper; teratogenesis; stage-dependent toxicity; AMPHITOX;

    机译：两栖类胚胎;铜;致畸作用阶段依赖性毒性;安非他命;

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