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首页> 外文期刊>Environmental toxicology and chemistry >THE ANTIMICROBIAL TRICLOCARBAN STIMULATES EMBRYO PRODUCTION IN THE FRESHWATER MUDSNAIL POTAMOPYRGUS ANTIPODARUM
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THE ANTIMICROBIAL TRICLOCARBAN STIMULATES EMBRYO PRODUCTION IN THE FRESHWATER MUDSNAIL POTAMOPYRGUS ANTIPODARUM

机译：抗菌三碳刺激胎生淡水鼠疫对虾的胚胎生产。

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摘要

Recent research has indicated that the antimicrobial chemical triclocarban (TCC) represents a new type of endocrine disruptor, amplifying the transcriptional activity of steroid hormones and their receptors while itself exhibiting little affinity for these receptors. The effects of TCC were studied in the freshwater mudsnail Potamopyrgus antipodarum. Specimens were exposed to concentrations ranging from 0.05 to 10.5 μg/L dissolved TCC and were removed and dissected, and embryos contained within the brood pouch were counted and classified as shelled or unshelled after two and four weeks of exposure. After four weeks, environmentally relevant TCC concentrations of 1.6 to 10.5 μg/L resulted in statistically significant increases in the number of unshelled embryos, whereas 0.2,1.6, and 10.5 μg/L exposures significantly increased numbers of shelled embryos. The lowest observed effect concentration (LOEC) was 0.2 μg/L, the no observed effect concentration (NOEC) was 0.05 μg/L; the 10% effective concentration (EC10) and the median effective concentration (EC50) for unshelled effects were 0.5 μg/L and 2.5 μg/L, respectively. Given the widespread occurrence of TCC in the environment and the effects shown at environmentally relevant concentrations, these results indicate that TCC may be causing reproductive effects in the environment. Furthermore, the present study indicates that environmental risk from a new class of endocrine-disrupting chemicals (EDCs) is both qualitatively and quantitatively similar to risk from existing classes of EDCs.
机译：最近的研究表明，抗菌化学三氯卡班（TCC）代表了一种新型的内分泌干扰物，可增强类固醇激素及其受体的转录活性，而其自身对这些受体的亲和力却很小。研究了TCC在淡水泥螺Potamopyrgus antipodarum中的作用。将标本暴露于浓度为0.05至10.5μg/ L的溶解TCC，取出并解剖，并在暴露两周和四周后对育雏袋中所含的胚胎进行计数并分类为带壳或不带壳。四周后，与环境有关的TCC浓度为1.6至10.5μg/ L导致带壳胚胎的数量在统计学上显着增加，而0.2、1.6和10.5μg/ L的暴露量显着增加了带壳胚胎的数量。最低观察效应浓度（LOEC）为0.2μg/ L，未观察效应浓度（NOEC）为0.05μg/ L；去壳效应的10％有效浓度（EC10）和中位有效浓度（EC50）分别为0.5μg/ L和2.5μg/ L。考虑到TCC在环境中的广泛发生以及在与环境有关的浓度下显示出的影响，这些结果表明TCC可能在环境中引起生殖影响。此外，本研究表明，新型内分泌干扰化学物质（EDC）带来的环境风险在质量和数量上都与现有EDC类别的风险相似。

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  • 来源
    《Environmental toxicology and chemistry》 |2010年第4期|p.966-970|共5页
  • 作者

    Ben D. Giudice; Thomas M. Young;

  • 作者单位

    Department of Civil and Environmental Engineering, University of California, Davis, One Shields Avenue, Davis, California 95616, USA;

    Department of Civil and Environmental Engineering, University of California, Davis, One Shields Avenue, Davis, California 95616, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    emerging contaminants; reproduction; endocrine disruptors; personal care products; snails;

    机译：新兴污染物;再生产;内分泌干​​扰物;个人护理产品;蜗牛;

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