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首页> 外文期刊>Environmental toxicology and chemistry >COMPLEX CONTAMINANT EXPOSURE IN CETACEANS: A COMPARATIVE E-SCREEN ANALYSIS OF BOTTLENOSE DOLPHIN BLUBBER AND MIXTURES OF FOUR PERSISTENT ORGANIC POLLUTANTS
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COMPLEX CONTAMINANT EXPOSURE IN CETACEANS: A COMPARATIVE E-SCREEN ANALYSIS OF BOTTLENOSE DOLPHIN BLUBBER AND MIXTURES OF FOUR PERSISTENT ORGANIC POLLUTANTS

机译：鲸类中复杂的污染物暴露：牛油性海豚脂和四种持久性有机污染物混合物的对比电子屏幕分析

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摘要

Cetaceans are federally protected species that are prone to accumulate complex mixtures of persistent organic pollutants (POPs), which individually may exert estrogenic or antiestrogenic effects. In the present study it was assessed whether contaminant mixtures harbored by cetaceans are estrogenic or antiestrogenic using a comparative approach. Interactions of antiestrogenic and estrogenic compounds were first investigated with the E-Screen assay using a mixture of four POPs (dichlorodiphenyldichloroethylene [4,4'-DDE], trans-nonachlor, and polychlorinated biphenyls [PCBs] 138 180) prevalent in cetacean blubber. Estrogenic/antiestrogenic activity was determined for the individual compounds and their binary, tertiary, and quaternary combinations. Significantly different responses were observed for the various POP mixtures, including enhanced estrogenic and antiestrogenic effects and antagonistic interactions. These results were then compared to the concentrations and estrogenic/antiestrogenic activity of contaminant mixtures isolated directly from the blubber of 15 bottlenose dolphins (Tursiops truncatus) collected from five U.S. Atlantic and Gulf of Mexico locations. The lowest observed effect concentrations (LOECs) determined for 4,4'-DDE (20 μmol/L), PCB 138 (20 μmol/L), PCB 180 (21 μmol/L), and trans-nonachlor (3 μmol/L) in the E-Screen were greater than estimated dolphin blood concentrations. Although estimated blood concentrations were below the LOECs, significant estrogenic activity was detected in diluted dolphin blubber from Cape May, NJ and Bermuda. Positive correlations between blubber estrogenicity and select POP concentrations (∑DDTs, ∑PBDEs, ∑HCB, ∑estrogenic PCBs, ∑estrogenic POPs) were also observed. Collectively, these results suggest that select bottlenose dolphin populations may be exposed to contaminants that act in concert to exert estrogenic effects at biologically relevant concentrations. These observations do not necessarily provide direct evidence of endocrine disruption; however, they may indicate an environmental source of xenoestrogenic exposure warranting future research.
机译：鲸类是受到联邦保护的物种，容易积累持久性有机污染物（POPs）的复杂混合物，而持久性有机污染物可能单独发挥雌激素或抗雌激素作用。在本研究中，使用比较方法评估了鲸类动物所携带的污染物混合物是雌激素还是抗雌激素。雌激素和雌激素化合物之间的相互作用首先通过E-Screen试验进行了研究，该混合物使用了鲸蜡类橡胶中常见的四种POP（二氯二苯基二氯乙烯[4,4'-DDE]，反式六氯和多氯联苯[PCB] 138 180）的混合物。测定了各个化合物及其二元，三元和四元组合的雌激素/抗雌激素活性。对于各种POP混合物，观察到明显不同的反应，包括增强的雌激素和抗雌激素作用以及拮抗作用。然后将这些结果与直接从15个宽吻海豚（Tursiops truncatus）的脂中分离出的污染物混合物的浓度和雌激素/抗雌激素活性进行了比较，这些海豚是从美国大西洋和墨西哥湾五个地点采集的。对4,4'-DDE（20μmol/ L），PCB 138（20μmol/ L），PCB 180（21μmol/ L）和反壬二氯（3μmol/ L）确定的最低观测效应浓度（LOEC） E-Screen中的）高于估计的海豚血液浓度。尽管估计的血液浓度低于LOECs，但在来自新泽西州梅普角和百慕大的稀释海豚脂中检测到显着的雌激素活性。润滑脂的雌激素性与选定的POP浓度（∑DDTs，∑PBDEs，∑HCB，∑雌激素多氯联苯，∑雌激素POPs）之间也呈正相关。总体而言，这些结果表明，某些宽吻海豚种群可能会暴露于污染物中，这些污染物在生物学相关浓度下会协同发挥雌激素作用。这些观察未必提供内分泌干扰的直接证据。然而，它们可能表明异种雌激素暴露的环境来源值得进一步研究。

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  • 来源
    《Environmental toxicology and chemistry》 |2010年第10期|p.2143-2153|共11页
  • 作者

    Jennifer E. Yordy; Meagan A.M. Mollenhauer; Rachel M. Wilson; Randall S. Wells; Aleta Hohn; Jay Sweeney; Lori H. Schwacke; Teri K. Rowles; John R. Kucklick; Margie M. Peden-Adams;

  • 作者单位

    Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, Charleston, South Carolina 29412, USA National Institute of Standards and Technology, Hollings Marine Laboratory, Charleston, South Carolina 29412, USA;

    rnMolecular and Cell Biology Program, Medical University of South Carolina, Charleston, South Carolina 29425, USA Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA;

    rnDepartment of Oceanography, Florida State University, Tallahassee, Florida 32306, USA;

    rnChicago Zoological Society c/o Mote Marine Laboratory, Sarasota, Florida 34236, USA;

    rnSoutheast Fisheries Science Center, National Marine Fisheries Service, Beaufort, North Carolina 28516, USA;

    rnDolphin Quest, 4467 Saratoga Ave, San Diego, California 93207, USA;

    rnCenter for Human Health Risks, National Oceanic and Atmospheric Administration, Hollings Marine Laboratory, Charleston, South Carolina USA;

    rnOffice of Protected Resources, National Marine Fisheries Service, Silver Spring, Maryland 20910, USA;

    rnNational Institute of Standards and Technology, Hollings Marine Laboratory, Charleston, South Carolina 29412, USA;

    rnMarine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, Charleston, South Carolina 29412, USA Molecular and Cell Biology Program, Medical University of South Carolina, Charleston, South Carolina 29425, USA Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA Mystic Aquarium and Institute for Exploration, Mystic, Connecticut 06355, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    persistent organic pollutants; contaminant mixtures; estrogenicity; antiestrogenicity; bottlenose dolphin;

    机译：持久性有机污染物;污染物混合物;雌激素抗雌激素宽吻海豚;

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