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首页> 外文期刊>Environmental toxicology and chemistry >CHRONIC EXPOSURE TO FLUOXETINE (PROZAC) CAUSES DEVELOPMENTAL DELAYS IN RANA PIPIENS LARVAE
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CHRONIC EXPOSURE TO FLUOXETINE (PROZAC) CAUSES DEVELOPMENTAL DELAYS IN RANA PIPIENS LARVAE

机译：长期接受氟西汀（PROZAC）致使蛙类幼虫发育迟缓

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摘要

Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are among the many Pharmaceuticals detected in aquatic ecosystems. Although the acute effects of SSRIs on select organisms have been reported, little is understood about the chronic effects of these drugs on amphibians, which are particularly sensitive to environmental pollutants. Serotonin plays important roles in many physiological functions, including a wide array of developmental processes. Exposure to SSRIs during development may cause developmental complications in a variety of organisms, but little is known about the degree of exposure necessary to cause deleterious effects. Here, we sought to gain a better understanding of the effects of SSRIs on amphibian development by use of a combined laboratory and outdoor mesocosm study. Tadpoles in a laboratory setting were exposed to a low (0.029 μg/L) and a high (0.29 μg/L) concentration of the common SSRI fluoxetine from stages 21 and 22 through completion of metamorphosis. Tadpoles in outdoor mesocosms were exposed to fluoxetine concentrations ranging from 0.1 to 0.3 μg/L. Exposed tadpoles in the laboratory showed delayed development compared with controls when stage was assessed throughout the experiment. Control tadpoles also gained weight faster than treatment tadpoles, which may be explained by reduced food intake. Mesocosm tadpoles exhibited similar trends, but no significant differences were detected. These results indicate that ecologically relevant levels of fluoxetine may cause developmental delays in amphibians.
机译：选择性5-羟色胺再摄取抑制剂（SSRI），例如氟西汀，是在水生生态系统中检测到的许多药物之一。尽管已经报道了SSRI对选定生物的急性作用，但对于这些药物对两栖动物的慢性影响知之甚少，而两栖动物对环境污染物特别敏感。 5-羟色胺在许多生理功能中起着重要作用，包括各种各样的发育过程。在发育过程中暴露于SSRIs可能会导致多种生物体的发育并发症，但对引起有害作用所必需的暴露程度知之甚少。在这里，我们试图通过结合使用实验室和室外中观研究来更好地了解SSRIs对两栖动物发育的影响。在实验室环境中，from从阶段21和阶段22到完成变态，都暴露于低（0.029μg/ L）和高（0.29μg/ L）的普通SSRI氟西汀浓度下。室外中me的暴露于氟西汀的浓度范围为0.1至0.3μg/ L。在整个实验过程中评估阶段时，实验室中暴露的t与对照组相比显示出发育延迟。对照t的体重也比治疗t快，这可以通过减少食物摄入量来解释。中观cos表现出相似的趋势，但未发现明显差异。这些结果表明，氟西汀的生态学相关水平可能导致两栖动物发育迟缓。

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  • 来源
    《Environmental toxicology and chemistry》 |2010年第12期|p.2845-2850|共6页
  • 作者

    Hannah R. Foster; G. Allen Burton; Niladri Basu; Earl E. Werner;

  • 作者单位

    Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA;

    School of Natural Resources and Environment and Cooperative Institute for Limnology and Ecosystems Research,University of Michigan, Ann Arbor, Michigan 48109, USA;

    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA;

    Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    pharmaceuticals; toxicity; selective serotonin reuptake inhibitor; amphibian; environment;

    机译：药品;毒性;选择性5-羟色胺再摄取抑制剂;两栖动物环境;

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