...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >BIOTRANSFORMATION OF THE 8:2 FLUOROTELOMER ACRYLATE IN RAINBOW TROUT. 1. IN VIVO DIETARY EXPOSURE
【24h】

BIOTRANSFORMATION OF THE 8:2 FLUOROTELOMER ACRYLATE IN RAINBOW TROUT. 1. IN VIVO DIETARY EXPOSURE

机译：虹鳟鱼中8：2氟代丙烯酸酯的生物转化。 1.体内饮食接触

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The bioaccumulation and biotransformation of the 8:2 fluorotelomer acrylate (C_8F_(17)CH_2CH_2OC(O)CH = CH_2, 8:2 FTAc) was investigated in rainbow trout via dietary exposure. The 8:2 FTAc is a monomer used in the manufacture of fluorinated polymers and has been widely detected in the atmosphere. The parent 8:2 FTAc and suspected intermediate and terminal metabolites were monitored in liver, blood, kidney, bile, and feces during the 5-d uptake and 8-d elimination phases using gas chromatography-mass spectrometry (GC-MS)- and liquid chromatography-tandem mass spectrometry (LC-MS/MS)- based methods. Very low levels of the 8:2 FTAc were detected in the internal tissues and feces, suggesting that the 8:2 FTAc was rapidly biotransformed in the gut or liver. Similarly, low concentrations of the 8:2 fluorotelomer alcohol (FTOH) were accumulated in the fish tissues. The 8:2 saturated fluorotelomer carboxylate (FTCA) was formed in the highest concentration, reaching steady-state tissue concentrations of approximately 1,000 to 1,400 ng/g wet weight. The 8:2 FTUCA and 7:3 FTCA were also accumulated in high levels, at levels approximately 10-fold lower than the 8:2 FTCA. Both the 7:3 FTCA and perfluorooctanoate (PFOA) showed increasing levels throughout the uptake phase and into the initial stages of the elimination phase, indicating continued formation through precursors still present in the body. Perfluorono-nanoate (PFNA) was formed in low nanogram per gram wet weight levels. The intermediate and terminal metabolites were also detected in the bile and feces, indicating an important elimination pathway for these compounds. In addition, the 8:2 FTOH glucuronide conjugate was measured in relatively high concentrations in the bile and feces. The results of the current study demonstrated a scenario in which a biologically labile compound is biotransformed to terminal metabolites that are much more biologically persistent.
机译：通过饮食接触研究了虹鳟鱼中8：2氟调聚物丙烯酸酯（C_8F_（17）CH_2CH_2OC（O）CH = CH_2，8：2 FTAc）的生物积累和生物转化。 8：2 FTAc是用于制造氟化聚合物的单体，并且已在大气中被广泛检测到。使用气相色谱-质谱法（GC-MS）在5d摄取和8d消除阶段监测母体8：2 FTAc以及怀疑的中间和终末代谢产物在肝脏，血液，肾脏，胆汁和粪便中的含量，并基于液相色谱-串联质谱（LC-MS / MS）的方法。在内部组织和粪便中检测到极低水平的8：2 FTAc，这表明8：2 FTAc在肠道或肝脏中迅速发生了生物转化。同样，低浓度的8：2氟调聚物醇（FTOH）积聚在鱼的组织中。以最高浓度形成8：2饱和氟调聚物羧酸盐（FTCA），达到约1,000至1,400 ng / g湿重的稳态组织浓度。 8：2 FTUCA和7：3 FTCA的含量也很高，比8：2 FTCA低约10倍。 7：3 FTCA和全氟辛酸酯（PFOA）在整个吸收阶段和消除阶段的初始阶段均显示出升高的水平，表明通过体内仍存在的前体持续形成。全氟壬酸酯（PFNA）的形成量为每克湿重低纳克。在胆汁和粪便中也检测到了中间代谢产物和最终代谢产物，表明这些化合物的重要消除途径。另外，在胆汁和粪便中以相对较高的浓度测量了8：2 FTOH葡糖醛酸苷共轭物。当前研究的结果表明了一种生物不稳定的化合物被生物转化为生物学上更持久的末端代谢物的情况。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号