Biotransformation Of Acridine By Mycobacterium Vanbaalenii

John B. Sutherland; Thomas M. Heinze; Mason G. Pearce; Joanna Deck; Anna J. Williams; James P. Freeman

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Biotransformation Of Acridine By Mycobacterium Vanbaalenii

机译：Vanbaalenii分枝杆菌对A啶的生物转化

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Cultures of Mycobacterium vanbaalenii strain PYR-1 in a liquid medium were exposed to the toxic environmental contaminant acridine (260 μM). After incubation for 7 d, the cultures were extracted with ethyl acetate. Metabolites were purified using high-performance liquid chromatography and analyzed by mass spectrometry and ~1H nuclear magnetic resonance spectroscopy. Four metabolites, 9,10-dihydroacridine, 4-hydroxyacridine, acridine cis-l,2-dihydrodiol, and acridin-9(10H)-one, were identified.

机译：将液体培养基中的Vanbaalenii分枝杆菌菌株PYR-1的培养物暴露于有毒的环境污染物a啶（260μM）。温育7天后，将培养物用乙酸乙酯萃取。使用高效液相色谱法纯化代谢产物，并通过质谱和〜1H核磁共振波谱进行分析。鉴定了四种代谢物9,10-二氢ac啶，4-羟基ac啶，a啶顺-1,2-二氢二醇和and啶9-9（10H）-one。

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《Environmental toxicology and chemistry》 |2009年第1期|61-64|共4页
作者
John B. Sutherland; Thomas M. Heinze; Mason G. Pearce; Joanna Deck; Anna J. Williams; James P. Freeman;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
acridine; azaarenes; biotransformation; mycobacteriurn vanbaalenii;

机译：cr啶;氮杂芳烃;生物转化;范氏分枝杆菌;

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1. Potential of Mycobacterium vanbaalenii as a model organism to study drug transporters of Mycobacterium tuberculosis, Mycobacterium marinum and Mycobacterium ulcerans: Homology analysis of M. tuberculosis drug transporters among mycobacterial species [J] . Gupta Anuj Kumar, Katoch V. M., Chauhan D. S., Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases . 2012,第4期

机译：范巴氏分枝杆菌作为研究结核分枝杆菌，海分枝杆菌和溃疡分枝杆菌的药物转运蛋白的模型生物的潜力：分枝杆菌种中结核分枝杆菌药物转运蛋白的同源性分析
2. A newly defined dioxygenase system from Mycobacterium vanbaalenii PYR-1 endowed with an enhanced activity of dihydroxylation of high-molecular-weight polyaromatic hydrocarbons [J] . Frontiers of environmental science & eng . 2020,第1期

机译：新定义的范巴伦分枝杆菌PYR-1双加氧酶系统具有增强的高分子量聚芳烃二羟基化活性
3. Erratum for Kweon et al., “Substrate Specificity and Structural Characteristics of the Novel Rieske Nonheme Iron Aromatic Ring-Hydroxylating Oxygenases NidAB and NidA3B3 from Mycobacterium vanbaalenii PYR-1” [J] . Ohgew Kweon, Seong-Jae Kim, James P. Freeman, MBio . 2020,第4期

机译：Kweon等人的错误，“新颖的Rieske Noneheme铁芳香族环 - 羟基羟基羟基酶NIDAB和NIDA3B3的底物特异性和结构特征来自<命名含量含量 - 型=”属型“>分枝杆菌vanbaalenii Pyr-1“
4. Proteomic Analysis of Mycobacterium vanbaalenii PYR-1 for the Elucidation of the Biodegradation Network of Polycyclic Aromatic Hydrocarbons [C] . Ricky D. Holland, Oh-Gew Kweon, Seong-Jae Kim, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：用于阐明多环芳烃生物降解网络的vanbaalenii pyr-1的蛋白质组学分析
5. Fungal Biotransformation of Polyfluoroalkyl Substances: Identification of Growth Substrates for Favorable Biotransformation Pathways [D] . Merino, Nancy Shiao-lynn. 2016

机译：多氟烷基物质的真菌生物转化：有利的生物转化途径的生长底物的鉴定。
6. Erratum for Kweon et al. Substrate Specificity and Structural Characteristics of the Novel Rieske Nonheme Iron Aromatic Ring-Hydroxylating Oxygenases NidAB and NidA3B3 from Mycobacterium vanbaalenii PYR-1 [O] . Ohgew Kweon, Seong-Jae Kim, James P. Freeman, 2020

机译：Kweon等人的错误新颖的Rieske Noneheme铁芳香环 - 羟基羟基氧化氧酸盐和Nida3b3的底物特异性和结构特征来自分枝杆菌vanbaalenii pyr-1
7. Erratum for Kweon et al., “Substrate Specificity and Structural Characteristics of the Novel Rieske Nonheme Iron Aromatic Ring-Hydroxylating Oxygenases NidAB and NidA3B3 from Mycobacterium vanbaalenii PYR-1” [O] . Ohgew Kweon, Seong-Jae Kim, James P. Freeman, 2020

机译：Kweon等人的错误，“新颖的Rieske Noneheme铁芳香环 - 羟基羟基氧化氧酸盐和Nida3b3的底物特异性和结构特征来自分枝杆菌vanbaalenii pyr-1”

Biotransformation Of Acridine By Mycobacterium Vanbaalenii

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