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首页> 外文期刊>Environmental toxicology and chemistry >FACTORS AFFECTING THE DEGRADATION OF PHARMACEUTICALS IN AGRICULTURAL SOILS
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FACTORS AFFECTING THE DEGRADATION OF PHARMACEUTICALS IN AGRICULTURAL SOILS

机译：影响农业土壤中农药降解的因素

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摘要

Pharmaceuticals may be released to the soil environment through the application of biosolids to land. To understand those factors affecting the pprsistence of Pharmaceuticals in the soil environment, the present study was performed to assess the effects of soil type, the presence of biosolids, and the impact of chemical mixture interactions on the degradation of three Pharmaceuticals: naproxen, carbamazepine, and fvoxetine. Single-compound studies showed that naproxen degraded in a range of soils with half-lives ranging from 3.1 to 6.9 d and in biosolids with a half-life of 10.2 d. No relationships were observed between degradation rate and soil physicochemical properties and soil bioactivity. For naproxen, addition of biosolids to soils reduced the degradation rate observed in the soil-only studies, with half-lives in the soil-biosolid systems ranging from 3.9 to 15.1 d. Carbamazepine and fluoxetine were found to be persistent in soils, biosolids, and soil-biosolid mixtures. When degradation was assessed using a mixture of the three study compounds and the sulfonamide antibiotic sulfamethazine, the degradation behavior of fluoxetine and carbamazepine was similar to that observed in the single compound studies (i.e., no degradation). However, the degradation rate of naproxen in soils, biosolids, and soil-biosolid systems spiked with the mixture was significantly slower than in the single-compound studies. As degradation studies for risk assessment purposes are performed using single substances in soil-only studies, it is possible that current risk assessment procedures will underestimate environmental impacts. Further work is therefore warranted on a larger range of substances, soils, biosolid types, and chemical mixtures to better understand the fate of Pharmaceuticals in terrestrial systems.
机译：药物可通过将生物固体应用于土地释放到土壤环境中。为了了解影响药物在土壤环境中使用的因素，本研究旨在评估土壤类型，生物固体的存在以及化学混合物相互作用对三种药物降解的影响：萘普生，卡马西平，和氟伏西汀。单化合物研究表明，萘普生在一系列土壤中降解，半衰期为3.1到6.9 d，在生物固体中半衰期为10.2 d。降解速率与土壤理化性质和土壤生物活性之间没有关系。对于萘普生，向土壤中添加生物固体降低了仅土壤研究中观察到的降解速率，土壤生物固体系统中的半衰期为3.9至15.1 d。发现卡马西平和氟西汀在土壤，生物固体和土壤-生物固体混合物中具有持久性。当使用三种研究化合物和磺酰胺抗生素磺胺二甲嘧啶的混合物评估降解时，氟西汀和卡马西平的降解行为与单个化合物研究中观察到的相似（即未降解）。但是，萘普生在掺入混合物的土壤，生物固体和土壤-生物固体系统中的降解速度明显慢于单一化合物的研究。由于仅在土壤研究中使用单一物质进行了用于风险评估目的的降解研究，因此当前的风险评估程序可能会低估环境影响。因此，有必要对更大范围的物质，土壤，生物固体类型和化学混合物进行进一步的研究，以更好地了解地面系统中药物的命运。

著录项

  • 来源
    《Environmental toxicology and chemistry》 |2009年第12期|2546-2554|共9页
  • 作者

    Sara C. Monteiro; Alistair B.A. Boxall;

  • 作者单位

    Environment Department, University of York, Heslington, York YO10 5DD, United Kingdom The Food and Environment Research Agency, Sand Hutton, York YO41 1LZ, United Kingdom;

    Environment Department, University of York, Heslington, York YO10 5DD, United Kingdom The Food and Environment Research Agency, Sand Hutton, York YO41 1LZ, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    pharmaceuticals; soil; biosolids; persistence;

    机译：药品;泥;生物固体坚持不懈;

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