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首页> 外文期刊>Environmental toxicology and chemistry >DOSE-DEPENDENT ENANTIOMERIC ENRICHMENT OF 2,2',3,3',6,6'-HEXACHLOROBIPHENYL IN FEMALE MICE
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DOSE-DEPENDENT ENANTIOMERIC ENRICHMENT OF 2,2',3,3',6,6'-HEXACHLOROBIPHENYL IN FEMALE MICE

机译：雌性小鼠中2,2'，3,3'，6,6'-六氯联苯的剂量依赖性对映体富集

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摘要

Nineteen of the 209 possible polychlorinated biphenyl (PCB) congeners are chiral and stable to racemization at ambient temperature. Chiral PCB congeners are important components of technical and environmental PCB mixtures, and some are highly toxic. Both environmental and laboratory studies have shown that these chiral PCB congeners undergo enantiomeric enrichment in many species; however, the processes and factors influencing the extent of this enantiomeric enrichment are poorly understood. We hypothesized that the exposure levels are an important factor affecting the extent of enantiomeric enrichment. To test this hypothesis, we investigated the levels and enantiomeric fractions of (±)-PCB 136 in selected tissues, feces, and urine of female C57Bl/6 mice 3 d after oral administration of 2.5, 10, or 50 mg/kg body weight of (±)-PCB 136. The PCB 136 tissue levels typically increased with increasing dose. The extent of the enrichment of (+)-PCB 136 in tissues and feces, however, decreased with increasing dose, an observation that suggests a saturation of the disposition process responsible for the enantiomeric enrichment. Overall, the present study demonstrates that in addition to species, exposure source, exposure frequency, and other factors, levels of PCB exposure are an important determinant of the enantiomeric enrichment of PCBs in mice and, most likely, other species.
机译：209种可能的多氯联苯（PCB）同类物中有19种在环境温度下是手性的且对消旋稳定。手性多氯联苯同类物是技术和环境多氯联苯混合物的重要成分，有些具有剧毒。环境和实验室研究均表明，这些手性多氯联苯同源物在许多物种中均经历对映体富集。然而，对这种对映体富集程度的过程和因素了解得很少。我们假设暴露水平是影响对映体富集程度的重要因素。为了检验该假设，我们研究了口服，口服2.5、10或50 mg / kg体重3天后，雌性C57Bl / 6小鼠的选定组织，粪便和尿液中（±）-PCB 136的水平和对映体分数（±）-PCB 136的含量。PCB136的组织水平通常随着剂量的增加而增加。然而，（+）-PCB 136在组织和粪便中的富集程度随剂量增加而降低，这一观察表明，对映异构体富集的处理过程已饱和。总体而言，本研究表明，除了物种，暴露源，暴露频率和其他因素外，PCB暴露水平也是小鼠和最可能其他物种中PCBs对映体富集的重要决定因素。

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  • 来源
    《Environmental toxicology and chemistry》 |2008年第2期|299-305|共7页
  • 作者

    Izabela Kania-Korwel; Keri C. Hornbuckle; Larry W. Robertson; Hans-Joachim Lehmler;

  • 作者单位

    Department of Occupational and Environmental Health, University of Iowa, College of Public Health, Iowa City, Iowa 52242, USA Department of Environmental Chemistry and Technology, University of Silesia, Szkolna 9, 40-006 Katowice, Poland;

    Department of Civil and Environmental Engineering, University of Iowa, Iowa City, Iowa 52242, USA;

    Department of Occupational and Environmental Health, University of Iowa, College of Public Health, Iowa City, Iowa 52242, USA;

    Department of Occupational and Environmental Health, University of Iowa, College of Public Health, Iowa City, Iowa 52242, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    polychlorinated biphenyls; ortho-substituted polychlorinated biphenyls; atropisomers; enantiomeric fraction; excretion;

    机译：多氯联苯;邻位取代的多氯联苯;阻转异构体对映体部分;排泄;

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