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COMMENT ON 'TOXICITY OF WEATHERED EXXON VALDEZ CRUDE OIL TO PINK SALMON EMBRYOS'

机译：关于“全天候埃克森·瓦尔迪兹原油对粉红鲑鱼胚膜的毒性”评论

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We take issue with an article by Brannon et al. [1] in Environmental Toxicology and Chemistry questioning the validity of our work on the toxicity of petroleum-derived polycyclic aromatic hydrocarbons (PAHs) to the early life stages of fish. Beginning in 1997, we published a series of articles demonstrating adverse effects in response to PAH exposure at concentrations in the low parts per billion [2-6]. Based on their attempt to reproduce our results, Brannon et al. [1] argue that the effects we described were an artifact caused by contact with PAH-laden oil microdroplets instead of dissolved PAHs and, therefore, that our results likely are not applicable to most field situations. The arguments advanced by Brannon et al. [1] are flawed for a number of reasons, and we stand by our published work. This letter focuses only on our fundamental concerns about the Brannon et al. article [1]. We have posted a detailed review at http://www.afsc.noaa.gov/ABL/Habitat/pdfs/review-3.pdf. Any scientist should welcome independent efforts at confirmation of his or her work, if only as an indication of its potential significance, and indeed we do. But equally, any scientist who attempts to confirm the results of another has an obligation to faithfully duplicate the important aspects of the experimental conditions employed. Failure to do so may produce results at odds with those of the original work.
机译：我们对布兰农等人的一篇文章持怀疑态度。 [1]在环境毒理学和化学中质疑我们关于石油衍生的多环芳烃（PAHs）对鱼类早期生命毒性的工作的有效性。从1997年开始，我们发表了一系列文章，证明了在十亿分之几的低浓度下，对PAH暴露的不良反应[2-6]。基于他们尝试重现我们的结果，Brannon等人。 [1]认为，我们描述的效应是由与富含PAH的油微滴而不是与溶解的PAH接触引起的人为产物，因此，我们的结果可能不适用于大多数现场情况。布兰农等人提出的论点。 [1]由于多种原因而存在缺陷，我们坚持发表的著作。这封信仅着眼于我们对Brannon等人的基本关注。第1条]。我们已经在http://www.afsc.noaa.gov/ABL/Habitat/pdfs/review-3.pdf上发布了详细的评论。任何科学家都应该欢迎独立努力来确认他或她的工作，即使只是为了表明其潜在的意义，我们也确实如此。但是同样地，任何试图确认另一人的结果的科学家都有义务忠实地复制所用实验条件的重要方面。否则可能会产生与原始作品不一致的结果。

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