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首页> 外文期刊>Environmental toxicology and chemistry >EFFECTS OF INGESTED NANO-SIZED TITANIUM DIOXIDE ON TERRESTRIAL ISOPODS (PORCELLIO SCABER)
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EFFECTS OF INGESTED NANO-SIZED TITANIUM DIOXIDE ON TERRESTRIAL ISOPODS (PORCELLIO SCABER)

机译：食用纳米级二氧化钛对陆地同位素（POSCELLIO SCABER）的影响

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摘要

The effects of ingested nano-sized titanium dioxide (TiO_2; anatase, 15 nm) on the terrestrial isopod Porcellio scaber (Isopoda, Crustacea) after short-term (3-d) dietary exposure were studied. Activities of antioxidant enzymes, such as catalase (CAT) and glutathione-S-transferase (GST), in digestive glands were affected in a dose-independent manner, but higher-level isopod endpoints, including weight change, feeding rate, food assimilation efficiency, and survival, were not affected up to the highest tested concentration of TiO_2 in food (3,000 (μg/g)- Exposure concentrations of 0.5, 2,000, and 3,000 fig nonsonicated TiO_2/g food decreased CAT and GST activities, but intermediate concentrations (1, 10, 100, and 1,000 (μg/g food) did not result in significant changes of enzyme activities. When the dispersion of TiO_2 was sonicated, no effects on enzyme activities or higher-level biomarkers were observed. The experimental setup with terrestrial isopods designed for dissolved chemicals also is suitable for testing the effects of ingested nanoparticles, but the presentation of toxicity data needs to be adapted according to the mode of action of the nanoparticles and their specific characteristics.
机译：研究了短期（3-d）饮食暴露后摄入的纳米二氧化钛（TiO_2；锐钛矿型，15 nm）对陆足等足类Porcellio scaber（Isopoda，Crustacea）的影响。消化腺中抗氧化酶（如过氧化氢酶（CAT）和谷胱甘肽-S-转移酶（GST））的活性不受剂量的影响，但等高脚等高点的终点包括体重变化，摄食率，食物同化效率在食品中测试的最高TiO_2浓度（3,000（μg/ g）时，其存活率和存活率均不受影响。暴露浓度为0.5、2,000和3,000图的未超声处理的TiO_2 / g食品中的CAT和GST活性降低，但中间浓度（ 1、10、100和1,000（μg/ g食物）不会导致酶活性的显着变化；超声处理TiO_2的分散液时，未观察到对酶活性或更高水平生物标志物的影响。专为溶解化学物质设计的等足动物也适合测试摄入的纳米颗粒的效果，但是毒性数据的显示需要根据纳米颗粒的作用方式及其规格进行调整ic特性。

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