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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Altered physiological conditions of the terrestrial isopod Porcellio scaber as a measure of subchronic TiO2 effects
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Altered physiological conditions of the terrestrial isopod Porcellio scaber as a measure of subchronic TiO2 effects

机译：改变陆足类足动物Porcellio scaber的生理状况，以衡量亚慢性TiO2的影响

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Titanium dioxide nanoparticles (nano-TiO2) show low toxic potential against a variety of environmental organisms when measured by conventional toxicity endpoints. However, the question is whether the conventional measures of toxicity can define the adverse effects of nanoparticles. The aim of this study was to asses the potential toxic and cytotoxic effects of the ingested nano-TiO2 (anatase, < 25 nm) on a terrestrial isopod, Porcellio scaber. In addition to conventional toxicity parameters, the physiological condition of the animals was assessed. Following 28-day feeding exposure to nano-TiO2 at concentrations up to 5,000 mu g nano-TiO2/g leaf dry weight, no toxic or cytotoxic effects were demonstrated. However, the physiological condition of the animals was affected in a dose-dependent manner. The physiological state of organisms is an important parameter to assess the potential population implications due to the exposure to nanomaterials. Therefore, we suggest that only if both, the physiological state of the animals exposed to nano-TiO2 and the conventional toxicity markers show no effects, the exposure dose can be interpreted as non-hazardous.
机译：当通过常规毒性终点测量时，二氧化钛纳米颗粒（纳米TiO2）对多种环境生物显示出低毒性潜力。然而，问题是毒性的常规措施是否可以确定纳米颗粒的不利影响。这项研究的目的是评估摄入的纳米TiO2（锐钛矿型，<25 nm）对陆地等足动物Porcellio scaber的潜在毒性和细胞毒性作用。除常规毒性参数外，还评估了动物的生理状况。饲喂28天饲喂的纳米TiO2浓度高达5,000μg纳米TiO2 / g叶片干重后，未显示毒性或细胞毒性作用。但是，动物的生理状况以剂量依赖的方式受到影响。生物的生理状态是评估由于暴露于纳米材料而潜在的种群影响的重要参数。因此，我们建议仅当暴露于纳米TiO2的动物的生理状态和常规毒性标记均未显示任何作用时，暴露剂量才能被解释为无害。

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