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首页> 外文期刊>Environmental toxicology and chemistry >MIXTURE AND SINGLE-SUBSTANCE TOXICITY OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS TOWARD ALGAE AND CRUSTACEANS
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MIXTURE AND SINGLE-SUBSTANCE TOXICITY OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS TOWARD ALGAE AND CRUSTACEANS

机译：选择性5-羟色胺再吸收抑制剂对藻类和甲壳类动物的混合物和单物质毒性

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Selective serotonin reuptake inhibitors (SSRIs) are used as antidepressant medications, primarily in the treatment of clinical depression. They are among the Pharmaceuticals most often prescribed in the industrialized countries. Selective serotonin reuptake inhibitors are compounds with an identical mechanism of action in mammals (inhibit reuptake of serotonin), and they have been found in different aqueous as well as biological samples collected in the environment. In the present study, we tested the toxicities of five SSRIs (citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline) as single substances and of citalopram, fluoxetine, and sertraline in binary mixtures in two standardized bioassays. Test organisms were the freshwater algae Pseudo-kirchneriella subcapitata and the freshwater crustacean Daphnia magna. In algae, test median effect concentrations (EC50s) ranged from 0.027 to 1.6 mg/L, and in daphnids, test EC50s ranged from 0.92 to 20 mg/L, with sertraline being one of the most toxic compounds. The test design and statistical analysis of results from mixture tests were based on isobole analysis. It was demonstrated that the mixture toxicity of the SSRIs in the two bioassays is predictable by the model of concentration addition. Therefore, in risk assessment based on chemical analysis of environmental samples, it is important to include the effect of all SSRIs that are present at low concentrations, and the model of concentration addition may be used to predict the combined effect of the mixture of SSRIs.
机译：选择性5-羟色胺再摄取抑制剂（SSRIs）用作抗抑郁药，主要用于临床抑郁症的治疗。它们是工业化国家/地区最常用的药品之一。选择性5-羟色胺再摄取抑制剂是在哺乳动物中具有相同作用机理的化合物（抑制5-羟色胺再摄取），并且已在环境中收集的不同水样和生物样品中发现了它们。在本研究中，我们通过两种标准化的生物测定法测试了5种SSRI（西酞普兰，氟西汀，氟伏沙明，帕罗西汀和舍曲林）作为单一物质的毒性以及西酞普兰，氟西汀和舍曲林在二元混合物中的毒性。测试生物是淡水藻类假单胞菌和淡水甲壳类水蚤（Daphnia magna）。在藻类中，测试中效浓度（EC50）为0.027至1.6 mg / L，在蚤类中，测试EC50为0.92至20 mg / L，舍曲林是毒性最高的化合物之一。混合测试结果的测试设计和统计分析均基于等边线分析。证明了两种生物测定法中SSRIs的混合毒性可以通过添加浓度模型来预测。因此，在基于环境样品化学分析的风险评估中，重要的是要包括所有低浓度存在的SSRI的作用，并且浓度添加模型可用于预测SSRI混合物的组合作用。

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