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首页> 外文期刊>Environmental toxicology and chemistry >ESTIMATING DIOXIN-LIKE POLYCHLORINATED BIPHENYL TOXIC EQUIVALENTS FROM TOTAL POLYCHLORINATED BIPHENYL MEASUREMENTS IN FISH
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ESTIMATING DIOXIN-LIKE POLYCHLORINATED BIPHENYL TOXIC EQUIVALENTS FROM TOTAL POLYCHLORINATED BIPHENYL MEASUREMENTS IN FISH

机译：从鱼中多氯联苯总测量中估算类似二恶英的多氯联苯有毒物

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摘要

Polychlorinated biphenyls (PCBs) are 209 related compounds, a dozen of which are known as dioxin-like PCBs (dl-PCBs) and are among the most toxic PCBs. Polychlorinated biphenyls contribute to many adverse effects to human health, including cancer, and are a major cause of fish advisories in North America, It is a common perception that individual PCB compounds, especially dl-PCBs, rather than total PCB need to be quantified to predict the environmental hazard because of differences in their toxicity potential and distribution among various environmental matrices, including aquatic food webs. Because the current analytical methods for quantifying dl-PCBs are complex and four- to fivefold more expensive, limited fish samples are analyzed for dl-PCBs. Using what likely is the largest dl-PCB fish data set (n = 912) with a wide distribution of fish species (n =22), size (19-112 cm), weight (100-14,300 g), sex (male:female, 51:49), and PCB contamination level (20-7,300 ng/g wet wt), we show that the comparatively less expensive and rapid measurements of total PCB in fish can be utilized to assess dl-PCB-related toxicological hazard, measured as 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalents (TEQ). A regression equation of dl-PCB-related TEQ (i.e., TEQ_(dl-PCB) ) to total PCB in fish is presented (TEQ_(dl-PCB) = [2.56 × 10~(-5)]C_(total PCB), r = 0.89, p < 0.001). The regression was evaluated by applying it to three independent data sets of substantial sizes (n = 55, 141, and 176). The TEQ_(dl-PCB) estimated using the regression and total PCB measurements were within a reasonable factor of two to three of the TEQ_(dl-PCB) calculated from the dl-PCB measurements. The successful evaluation indicates versatility of the regression.
机译：多氯联苯（PCB）是209种相关化合物，其中十二种被称为二恶英样PCB（dl-PCBs），是毒性最高的PCB之一。多氯联苯对人类健康（包括癌症）造成许多不利影响，并且是北美鱼类咨询的主要原因。人们普遍认为，需要对单个PCB化合物（尤其是dl-PCBs）进行量化，而不是对全部PCB进行量化。由于其潜在毒性和在包括水生食物网在内的各种环境基质之间的分布差异，可以预测环境危害。由于当前用于定量dl-PCBs的分析方法很复杂，而且价格昂贵四到五倍，因此对有限的鱼类样品中的dl-PCBs进行了分析。使用可能是最大的dl-PCB鱼数据集（n = 912），其中鱼种类广泛（n = 22），大小（19-112 cm），体重（100-14,300 g），性别（男性：女性（51:49）和多氯联苯污染水平（20-7,300 ng / g湿重），我们发现鱼中多氯联苯的相对便宜和快速的测量可用于评估dl-PCB相关的毒理危害，测定为2,3,7,8-四氯二苯并-对二恶英的毒性当量（TEQ）。提出了与鱼类体内多氯联苯有关的dl-PCB相关TEQ（即TEQ_（dl-PCB））对总PCB的回归方程（TEQ_（dl-PCB）= [2.56×10〜（-5）] C_（总PCB） ，r = 0.89，p <0.001）。通过将回归应用于三个独立的数据集（n = 55、141和176）进行评估。使用回归和总PCB测量值估算的TEQ_（dl-PCB）在从dl-PCB测量值计算出的TEQ_（dl-PCB）的二至三倍的合理范围内。成功的评估表明回归的多功能性。

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  • 来源
    《Environmental toxicology and chemistry》 |2007年第8期|1622-1628|共7页
  • 作者

    Satyendra P. Bhavsar; Alan Hayton; Eric J. Reiner; Donald A. Jackson;

  • 作者单位

    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada Environmental Monitoring and Reporting Branch, Ontario Ministry of the Environment, 125 Resources Road, Toronto, Ontario M9P 3V6, Canada;

    Environmental Monitoring and Reporting Branch, Ontario Ministry of the Environment, 125 Resources Road, Toronto, Ontario M9P 3V6, Canada;

    Laboratory Services Branch, Ontario Ministry of the Environment, 125 Resources Road, Toronto, Ontario M9P 3V6, Canada;

    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    toxic equivalents; polychlorinated biphenyls; dioxin-like polychlorinated biphenyls; fish advisory; analytical method;

    机译：有毒当量多氯联苯;二恶英样多氯联苯;鱼类咨询;分析方法;

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