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首页> 外文期刊>Environmental toxicology and chemistry >SUBCHRONIC ORGANISMAL TOXICITY, CYTOTOXICITY, GENOTOXICITY, AND FEEDING RESPONSE OF PACIFIC OYSTER (CRASSOSTREA GIGAS) TO LINDANE (γ-HCH) EXPOSURE UNDER EXPERIMENTAL CONDITIONS
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SUBCHRONIC ORGANISMAL TOXICITY, CYTOTOXICITY, GENOTOXICITY, AND FEEDING RESPONSE OF PACIFIC OYSTER (CRASSOSTREA GIGAS) TO LINDANE (γ-HCH) EXPOSURE UNDER EXPERIMENTAL CONDITIONS

机译：实验条件下太平洋牡蛎（CRASSOSTREA GIGAS）对林丹（γ-HCH）暴露的亚慢性有机毒性，细胞毒性，遗传毒性和饲料反应

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摘要

This study evaluated organismal toxicity, cytotoxicity, and genotoxicity and the filtration rate in response to different concentrations of subchronic lindane (gamma-hexachlorocyclohexane [γ-HCH]), exposure (12 d) in adult Pacific oysters Crassostrea gigas. Oysters were exposed in vivo in laboratory aquaria to 10 different concentrations (0.0-10.0 mg/L) of γ-HCH. The median lethal concentration (LC50) after 12 d was calculated as 2.22 mg/L. Cytotoxic effects were observed in hemocytes, where the mean cell viability was significantly decreased at 1.0 mg/L of γ-HCH after 12 d. Genotoxicity of 7-HCH measured by single cell gel electrophoresis assay, in hemocytes was evident at 0.7 mg/L of γ-HCH after 12 d. After 4 h of exposure to γ-HCH, filtration rates were reduced compared with controls to 65.8 and 38.2% at concentrations of 0.3 and 0.7 mg/L, respectively, and after 11 d of exposure, filtration rates were reduced to 60.4 and 30.9% at concentrations of 0.1 mg/L and higher. These results show the subchronic effects of γ-HCH at different concentrations and effect sensitivities are categorized as filtration rate < genotoxicity < cytotoxicity < mortality. The relevance of integral toxicity evaluation, considering different endpoints from molecular, cellular, and individual levels is discussed.
机译：这项研究评估了成年太平洋牡蛎Crassostrea gigas对亚慢性林丹（γ-六氯环己烷[γ-HCH]）的不同浓度，暴露（12 d）的反应的生物毒性，细胞毒性和遗传毒性以及过滤速率。牡蛎在实验室水族馆中体内暴露于10种不同浓度（0.0-10.0 mg / L）的γ-六氯环己烷。 12 d后的中位致死浓度（LC50）计算为2.22 mg / L。在血细胞中观察到了细胞毒性作用，其中在12 d后平均细胞活力在1.0 mg / L的γ-六氯环己烷中显着降低。通过单细胞凝胶电泳法测定的7-六氯环己烷在血细胞中的基因毒性在0.7毫克/升的γ-六氯环己烷在12天后很明显。暴露于γ-HCH中4小时后，在0.3和0.7 mg / L的浓度下，与对照组相比，过滤率分别降低至65.8和38.2％；暴露11 d后，过滤率降至60.4和30.9％浓度为0.1 mg / L或更高。这些结果表明，γ-六氯环己烷在不同浓度下具有亚慢性效应，其效应敏感性归类为过滤率<基因毒性<细胞毒性<细胞毒性<死亡率。讨论了整体毒性评估的相关性，考虑了分子，细胞和个体水平的不同终点。

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  • 来源
    《Environmental toxicology and chemistry》 |2007年第10期|2192-2197|共6页
  • 作者

    Gerardo Anguiano; Raul Liera-Herrera; Emilio Rojas; Celia Vazquez-Boucard;

  • 作者单位

    Department of Environmental Management and Conservation, Toxicogenomic and Reproduction of Aquatic Organism Laboratory (CIBNOR), P.O. 128, La Paz, Baja California Sur, Mexico;

    Department of Environmental Management and Conservation, Toxicogenomic and Reproduction of Aquatic Organism Laboratory (CIBNOR), P.O. 128, La Paz, Baja California Sur, Mexico;

    Department of Genomic and Environmental Toxicology Medicine. Toxicogenomic Laboratory. IIB-UNAM. Ciudad de Mexico, Mexico;

    Department of Environmental Management and Conservation, Toxicogenomic and Reproduction of Aquatic Organism Laboratory (CIBNOR), P.O. 128, La Paz, Baja California Sur, Mexico;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    lindane; crassostrea gigas; comet assay; biomarkers; stress response;

    机译：林丹猪笼草彗星试验生物标志物压力反应;

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